Results 131 to 140 of about 5,776,246 (295)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Mycobacterium avium ssp. paratuberculosis and Crohn’s Disease—Diagnostic Microbiological Investigations Can Inform New Therapeutic Approaches

Antibiotics
Mycobacterium avium ssp. paratuberculosis (MAP) is the cause of Johne’s disease (JD), which is a chronic infectious gastrointestinal disease of ruminants and is often fatal. In humans, MAP has been associated with Crohn’s disease (CD) for over a century,
John M. Aitken, Jack E. Aitken, Gaurav Agrawal   +2 more
doaj   +1 more source

Identification of a cellular node for motor control pathways

, 2014
Ariel J. Levine, Christopher A. Hinckley, Kathryn L. Hilde, Shawn P. Driscoll, Tiffany Poon, Jessica M. Montgomery, Samuel L. Pfaff   +6 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The role of a community health worker-delivered preconception and pregnancy intervention in achieving a more positive pregnancy experience: the Bukhali trial in Soweto, South Africa

BMC Women's Health
Background A patient-centered, human-rights based approach to maternal care moves past merely reducing maternal mortality and morbidity, towards achieving a positive pregnancy experience.
Larske M. Soepnel, Khuthala Mabetha, Shane A. Norris, Molebogeng Motlhatlhedi, Nokuthula Nkosi, Sonja Klingberg, Stephen Lye, Catherine E. Draper   +7 more
doaj   +1 more source

Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease ‐like colitis via the Axin2/GSK3β pathway

, 2022
Jing Li, Lugen Zuo, Zhijun Geng, Qingqing Li, Cheng Yang, Zi Yang, Ruohan Shi, Yueqing Zhou, Wenhu Nie, Yueyue Wang, Xiaofeng Zhang, Sitang Ge, Xue Song, Jianguo Hu   +13 more
openalex   +1 more source

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Science, 2008
Siân Jones, Xiaosong Zhang, D. W. Parsons, Jimmy Lin, R. Leary, P. Angenendt, P. Mankoo, H. Carter, H. Kamiyama, A. Jimeno, Seung‐Mo Hong, Baojin Fu, Ming-Tseh Lin, E. Calhoun, M. Kamiyama, K. Walter, T. Nikolskaya, Y. Nikolsky, James J. Hartigan, Douglas R. Smith, M. Hidalgo, S. Leach, A. Klein, E. Jaffee, M. Goggins, A. Maitra, C. Iacobuzio-Donahue, J. Eshleman, S. Kern, R. Hruban, R. Karchin, N. Papadopoulos, G. Parmigiani, B. Vogelstein, V. Velculescu, K. Kinzler   +35 more
semanticscholar   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Signaling Pathways and Genes Associated with Hexavalent Chromium-Induced Hepatotoxicity

, 2022
Xiaofeng Li, Abdel‐Moneim Eid Abdel‐Moneim, Bing Yang   +2 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source