Results 131 to 140 of about 7,950,605 (408)

Atrial Fibrillation and Risk of Cancer: A Danish Population‐Based Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Atrial fibrillation (AF) and cancer are frequent diseases worldwide. The timewise association between the diagnosis of AF and a subsequent diagnosis of cancer may clarify whether a mutual cause exists, and may also guide clinicians about time ...
Nicklas Vinter, Amanda M. S. Christesen, Morten Fenger‐Grøn, Anne Tjønneland, Lars Frost   +4 more
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Nonlinear spectroscopy with entangled photons; manipulating quantum pathways of matter [PDF]

arXiv, 2009
Optical signals obtained by the material response to classical laser fields are given by nonlinear response functions which can be expressed by sums over various quantum pathways of matter. We show that some pathways can be selected by using nonclassical fields, through the entanglement of photon and material pathways, which results in a different ...
arxiv  

Patient characteristics and healthcare utilisation among Danish patients with chronic conditions: a nationwide cohort study in general practice and hospitals

BMC Health Services Research, 2020
Background The complexity of caring for patients with chronic conditions necessitates new models of integrated care to accommodate an increasing demand.
Anders Damgaard Møller Schlünsen, David Høyrup Christiansen, Ulrich Fredberg, Peter Vedsted   +3 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

The impact of reforms on labour market exit probabilities [PDF]

Early retirement schemes and disability insurance in the Netherlands have both been reformed during the past decades. The reforms have increased incentives to continue working and have decreased the substitution between early retirement and disability ...
Annemiek van Vuren, Daniel van Vuuren, Rob Euwals   +2 more
core  

Adaptive modeling of biochemical pathways [PDF]

, 2010
In bioinformatics, biochemical pathways can be modeled by many differential equations. It is still an open problem how to fit the huge amount of parameters of the equations to the available data.
Brause, Rüdiger W.
core  

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Folding Pathways of Prion and Doppel [PDF]

, 2002
The relevance of various residue positions for the stability and the folding characteristics of the prion protein are investigated by using molecular dynamics simulations of models exploiting the topology of the native state.
Alm, Amos Maritan, Baker, Baskakov, Brooks, Calzolai, Cecconi, Clementi, Cristian Micheletti, Dlouhy, Ferrara, Ferrenberg, Gabizon, Galzitskaya, Garcia, Giovanni Settanni, Glockshuber, Go, Goldgaber, Gsponer, Hao, Hoang, Hoang, Hsiao, Huang, James, Kaya, Kaya, Kretzschmar, Liu, Maritan, Maritan, Martinez, Micheletti, Micheletti, Micheletti, Mo, Munoz, Nicholson, Ozkan, Pan, Pearlman, Peretz, Pergami, Petersen, Plaxco, Poulter, Prusiner, Riddle, Sakaguchi, Settanni, Trinh Xuan Hoang, Tsai, Wildegger, Zahn   +54 more
core   +3 more sources