Results 131 to 140 of about 2,920,676 (267)

Kelulut honey (<i>Heterotrigona itama</i>) as a multi-target neuroprotective strategy against bisphenol A-induced neurotoxicity. [PDF]

Toxicol Rep
Azmi SK, Ali NF, Siran R.
europepmc   +1 more source

Taxane pathway [PDF]

Pharmacogenetics and Genomics, 2009
Connie, Oshiro, Sharon, Marsh, Howard, McLeod, Michelle Whirl, Carrillo, Teri, Klein, Russ, Altman   +5 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Evolutionary Analysis of Trehalose Breakdown Pathways. [PDF]

Genome Biol Evol
Muthu G G, Laxman S, Seshasayee ASN.
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Pilot Randomized Trial of a Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer. [PDF]

J Pain Symptom Manage
Lau-Min KS, Psenka R, Holtze M, Metri C, Hansen A, Lo SB, Decker V, Manz CR, Parikh A, Nipp R, El-Jawahri A, Temel JS, Traeger L.   +12 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Unraveling the complex web of acute kidney injury: pathways, biomarkers, and future directions. [PDF]

J Bras Nefrol
Zha C, Qi Y, Yang, Li G, He Z, Xu D, Li J.   +6 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source