Results 161 to 170 of about 5,642,885 (289)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Care Pathways for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-The-Art Review. [PDF]

Liver Int
van Eekhout KMA, Broekman LD, de Jong VD, Michel M, Grobbee R, Maya-Miles D, Romero-Gómez M, Muris J, Mendive JM, Vali Y, Franco OH, Schattenberg JM, Fournier-Poizat C, Castro Cabezas M, Tushuizen ME, Holleboom AG.   +15 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Transcriptomic and metabolomic profiling reveals media- and host-dependent responses to <i>Staphylococcus hominis</i> in cell models. [PDF]

PeerJ
Liu W, Zhang T, Wang Q, Li Z, Bai Y, Xiao H, Wang Y, Xiao R, Tong L, Li Y, Qu X, Zhao X, Zhang Z, Sun H.   +13 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Flexible Bayesian Inference for Identifying Significantly Correlated Multiple Pathway Sets. [PDF]

Stat Med
Jin P, Yun Y, Kim I.
europepmc   +1 more source

Exploring Pathways to Reconciliation [PDF]

, 2016
Absolon, Kathleen E., Absolon-Winchester, Akiesha E.   +1 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A transcriptomic resource for glial GABA-associated ASH neuronal aging and candidate pathways. [PDF]

Front Aging Neurosci
Al-Sheikh U, Cheng H, Bakrbaldawi AAA, He L, Chen D, Zhan R, Kang L, Zhang Y.   +7 more
europepmc   +1 more source

Taxane pathway [PDF]

Pharmacogenetics and Genomics, 2009
Connie, Oshiro, Sharon, Marsh, Howard, McLeod, Michelle Whirl, Carrillo, Teri, Klein, Russ, Altman   +5 more
openaire   +2 more sources