Results 11 to 20 of about 7,950,605 (408)
Fast Identification of Biological Pathways Associated with a Quantitative Trait Using Group Lasso with Overlaps [PDF]
Statistical Applications in Genetics and Molecular Biology, Volume
11, Issue 1, Article 7, 2012, 2012 Where causal SNPs (single nucleotide polymorphisms) tend to accumulate within biological pathways, the incorporation of prior pathways information into a statistical model is expected to increase the power to detect true associations in a genetic ...
,, Montana, Giovanni, Silver, Matt
core +5 more sources
Identification of gene pathways implicated in Alzheimer's disease using longitudinal imaging phenotypes with sparse regression [PDF]
arXiv, 2012 We present a new method for the detection of gene pathways associated with a multivariate quantitative trait, and use it to identify causal pathways associated with an imaging endophenotype characteristic of longitudinal structural change in the brains ...
Alzheimer's Disease Neuroimaging Initiative +5 more
core +3 more sources
Pharmacogenetics and Genomics, 2010 The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g. Crohn’s disease and rheumatoid arthritis) and of organ transplant recipients. As inactive prodrugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and azathioprine require intracellular activation, catalyzed by ...
Gianluigi Zaza +11 more
openaire +7 more sources
Developmental Cell, 2011 Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission.
Scott D. Emr +2 more
openaire +3 more sources
The Pathway Tools Pathway Prediction Algorithm [PDF]
Standards in Genomic Sciences, 2011 The PathoLogic component of the Pathway Tools software performs prediction of metabolic pathways in sequenced and annotated genomes. This article provides a detailed presentation of the PathoLogic algorithm. The algorithm consists of two phases. The reactome inference phase infers the reactions catalyzed by the organism from the set of enzymes present ...
Ron Caspi +2 more
openaire +2 more sources
BMC Public Health, 2023 Background Multimorbidity-risk is established early in life, therefore reducing modifiable risk factors such as overweight or obesity may, in part, tackle the burden of multimorbidity in later life.
Ashleigh Craig +4 more
doaj +1 more source
Targeting cancer stem cell pathways for cancer therapy
Signal Transduction and Targeted Therapy, 2020 Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been considered promising therapeutic targets for cancer therapy. These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor ...
Liqun Yang +10 more
semanticscholar +1 more source
KEGG: new perspectives on genomes, pathways, diseases and drugs
Nucleic Acids Res., 2016 KEGG (http://www.kegg.jp/ or http://www.genome.jp/kegg/) is an encyclopedia of genes and genomes. Assigning functional meanings to genes and genomes both at the molecular and higher levels is the primary objective of the KEGG database project.
M. Kanehisa +4 more
semanticscholar +1 more source
Nucleic Acids Research, 2015 PathWhiz (http://smpdb.ca/pathwhiz) is a web server designed to create colourful, visually pleasing and biologically accurate pathway diagrams that are both machine-readable and interactive. As a web server, PathWhiz is accessible from almost any place and compatible with essentially any operating system. It also houses a public library of pathways and
Michael Wilson +7 more
openaire +3 more sources
Antioxidants, 2019 Bioactive phytochemicals in Rosmarinus officinalis, Withania somnifera, and Sophora japonica have a long history of human use to promote health. In this study we examined the cellular effects of a combination of extracts from these plant sources based on
Brooks M. Hybertson +3 more
doaj +1 more source