Results 201 to 210 of about 5,776,246 (295)

Robust and Sustained STING Pathway Activation via Hydrogel-Based In Situ Vaccination for Cancer Immunotherapy

Sheng‐Liang Cheng, H.T. Lee, Chung‐Pin Li, Mei‐Wei Lin, Min‐Yuan Chou, Yu‐Ting Yen, T. B. Wu, Yajie Lian, Yu-Chuan Shih, Chi‐Shiun Chiang, Ting-Wen Chen, Dehui Wan, Yunching Chen   +12 more
openalex   +1 more source

Effect of Dietary Lactobacillus plantarum Supplementation on the Growth Performance, Intestinal Health, Antioxidant Capacity, and mTOR Signaling Pathway of Juvenile Coho Salmon (Oncorhynchus kisutch) [PDF]

Qin Zhang, Lan Li, Rongxin Qin, Liuqing Meng, Dongsheng Liu, Tong Tong, Lixiao Xu, Yongqiang Liu, Weiguang Kong   +8 more
openalex   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

The Gut Microbiota-Insulin Resistance Axis: Mechanisms, Clinical Implications, and Therapeutic Potential. [PDF]

FASEB Bioadv
Al Qassab M, Chaarani N, Hamou A, Harb R, Jradi A, Zeineddine M, Ghadieh HE, Khattar ZA, Azar S, Kanaan A, Harb F.   +10 more
europepmc   +1 more source

Long Noncoding RNAs in Cancer Pathways.

Cancer Cell, 2016
A. Schmitt, Howard Y. Chang
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Uncovering coordinated pathway interactions through gene co-differential expression in yeast. [PDF]

Nucleic Acids Res
Nasar MI, Sabih Ur Rehman S, Ott S, Alam MT.   +3 more
europepmc   +1 more source

Detecting infiltrated water and preferential flow pathways through time-lapse ground-penetrating radar surveys

, 2020
Simone Di Prima, Thierry Winiarski, Rafaël Angulo-Jaramillo, Ryan D. Stewart, Mirko Castellini, Majdi Abou Najm, Domenico Ventrella, Mario Pirastru, Filippo Giadrossich, Giorgio Capello, Marcella Biddoccu, Laurent Lassabatère   +11 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

DNA variants affecting chromatin structure are key to the genetic architecture of obsessive compulsive disorder. [PDF]

Epigenetics Chromatin
Han VX, Patel S, Mohammad SS, Dale RC.
europepmc   +1 more source