Results 251 to 260 of about 2,463,634 (361)

The use of patient reported outcome measures (PROMs) in clinical assessment. [PDF]

, 2018
Black, Bradbury-Jones, Burton, Dawson, Drozd, Equality Act, Flynn, Goldbart, Harris, Haywood, Jette, Jones, Kavanagh, Kyte, MacArthur, Mansell, Murray, Nelson, RCN, Streiner, Wylde   +20 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Patient-Reported Outcome Measures in Safety Event Reporting: PROSPER Consortium Guidance [PDF]

, 2013

core   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

The Development and Validation of a Multidimensional Sum-Scaling Questionnaire to Measure Patient-Reported Outcomes in Acute Respiratory Tract Infections in Primary Care: The Acute Respiratory Tract Infection Questionnaire [PDF]

, 2013
Rune Aabenhus, Hanne Thorsen, Volkert Siersma, John Brodersen   +3 more
openalex   +1 more source

Weakly supervised text classification on free-text comments in patient-reported outcome measures. [PDF]

Front Digit Health
Linton AG, Dimitrova VG, Downing A, Wagland R, Glaser AW.   +4 more
europepmc   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Patient-Reported Outcome Measures for Systemic Lupus Erythematosus Clinical Trials: A Content Validity and Psychometric Performance Review [PDF]

, 2013
L. Humphrey, Louise Heron, C. Pilling, Laura Holloway, Lise Højbjerre, Martin Strandberg-Larsen, B.B. Hansen   +6 more
openalex   +1 more source

Communication Patient Reported Outcome Measures for Adults With Communication Disorders: A Systematic Review of Content Validity. [PDF]

Int J Lang Commun Disord
Van Ewijk L, Hilari K, Pais A, Volkmer A.   +3 more
europepmc   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source