Results 181 to 190 of about 68,345,786 (284)

Patient‐oriented Research in the Era of Personalized Medicine [PDF]

Clinical and Translational Science, 2012
openaire   +2 more sources

Optimism, ambivalence, and opportunities: staff perspectives signaling a critical turn in patient-oriented research in forensic mental health care settings. [PDF]

Front Psychiatry
Canning C, Procknow G.
europepmc   +1 more source

A patient-oriented research approach to assessing patients' and primary care physicians' opinions on trauma-informed care. [PDF]

PLoS One, 2021
Kokokyi S, Klest B, Anstey H.
europepmc   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

Co-development and Usability Testing of Research 101: A Patient-Oriented Research Curriculum in Child Health (PORCCH) E-Learning Module for Patients and Families. [PDF]

Front Pediatr, 2022
Walsh CM, Jones NL, McCreath GA, Connan V, Pires L, Chen AQH, Karoly A, Macarthur C.   +7 more
europepmc   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Learning to work together: experiences of researchers and family partners in a patient-oriented research team. [PDF]

Res Involv Engagem
Ribeiro MDS, Compton RM, Ottley KM, Barlow M, Craswell A, Emard S, McPhee J, Moorman M.   +7 more
europepmc   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Empowering partnership: key lessons from the co-development of patient-oriented research with parents, researchers, and healthcare professionals. [PDF]

Front Health Serv
Wilson JM, Kromm SK, Johns C, Neraasen ML, Chinhengo T, Anderson SD, Fiedrich E, McNeil D.   +7 more
europepmc   +1 more source

Codevelopment and usability testing of Patient Engagement 101: a Patient-Oriented Research Curriculum in Child Health e-learning module for health care professionals, researchers and trainees. [PDF]

CMAJ Open, 2022
Walsh CM, Jones NL, McCreath GA, Connan V, Pires L, Abuloghod L, Buchanan F, Macarthur C.   +7 more
europepmc   +1 more source