Results 131 to 140 of about 1,336,012 (296)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Risk Factors for Hospital Malpractice Exposure: Implications for Managers and Insurers [PDF]

, 1991
The possibility of identifying certain variables that might serve as predictors of above- or below-average medical malpractice claims experience was explored.
Katz, Patricia P., Luft, Harold S., Pinney, Douglas G.   +2 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

How patient-reported outcomes and experience measures (PROMs and PREMs) are implemented in healthcare professional and patient organizations? An environmental scan

Journal of Patient-Reported Outcomes
Background Patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) are becoming essential parts of a learning health system, and using these measures is a promising approach for value-based healthcare. However, evidence
Véronique Lowry, Vanessa Tremblay-Vaillancourt, Priscilla Beaupré, Marie-Dominique Poirier, Marie-Ève Perron, Jessica Bernier, Anaëlle Morin, Caroline Cormier, Jeannie Haggerty, Sara Ahmed, Magaly Brodeur, Geneviève David, Sylvie Lambert, Maude Laberge, Diana Zidarov, Regina Visca, Thomas G. Poder, Hervé Tchala Vignon Zomahoun, Maxime Sasseville, Marie-Eve Poitras   +19 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Using patient-generated health data more efficient and effectively to facilitate the implementation of value-based healthcare in the EU – Innovation report

Computational and Structural Biotechnology Journal
Healthcare services and products are rapidly changing due to the development of new technologies, offering relevant solutions to improve patient outcomes.
Frans Folkvord, Jim Ingebretsen Carlson, Manuel Ottaviano, Diego Carvajal, Liss Hernandez Gonzalez, Rens van de Schoot, Eva Turk, Jordi Piera-Jiménez, Caridad Pontes, Marina Ramiro-Pareta, Gerard Carot-Sans, Eva Podovšovnik, Vesna Levašič, Kathrin Scheckenbach, Martin Wagenmann, Aron Szpisjak, Bogi Eliasen, Joe-Max Wakim, Martin Ernst, Yvonne Prinzellner, Nadine Bol, Linwei He, Emiel Krahmer, Clàudia Navarro, Laia Juan, Davide Guerri, Laura Pinna, Carmela Genovese, Luciano Benetti, Chiara Macagnano, Franco Chiarugi, Johannes Peeters, Ludovico Pedullà, Giampaolo Brichetto, Paola Zaratin, Seldag Gunes Peschke, Lutz Peschke, Giuseppe Fico   +37 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

#1204 Measuring needling experience: development and validation of the Needling Patient Reported Experience Measure (NPREM)

Nephrology Dialysis Transplantation
Abstract Background and Aims Most people on haemodialysis rely on having reliable access to their vascular system, often via surgically created arteriovenous fistula or graft. At the beginning of each dialysis session, needles must be inserted. While ‘needling’ is a key step, an annual UK survey shows
Currie Moore, Rebacca Flanagan, Amanda Busby, Helen Ellis-Caird, Faizan Khalid Awan, Tarsem Paul, Catherine Fielding, Kieran Mccafferty, Sabine van der Veer, Janine Hawkins, Kenneth Farrington, David Wellsted   +11 more
openaire   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

International cross-cultural development and field testing of the primary care practice questionnaire for the PaRIS survey (PaRIS-PCPQ)

BMC Primary Care
Background The PaRIS survey, an initiative of the Organisation for Economic Co-operation and Development (OECD), aims to assess health systems performance in delivering primary care by measuring the care experiences and outcomes of people over 45 who ...
Janika Bloemeke-Cammin, Oliver Groene, Marta Ballester, Frederico Guanais, Peter Groenewegen, Candan Kendir, Ian Porter, Amun Rehsi, Mieke Rijken, Peter Spreeuwenberg, Rosa Suñol, Jose Maria Valderas, Rachel Williams, Michael van den Berg   +13 more
doaj   +1 more source