Results 131 to 140 of about 7,676,849 (387)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Journal of Patient-Reported Outcomes, 2019 BackgroundPatient reported outcomes (PROs) provide information on a patient’s health status coming directly from the patient. Measuring PROs with patient reported outcome measures (PROMs) has gained wide interest in clinical practice for individual ...
P. J. van der Wees +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Incorporating development of a patient-reported outcome instrument in a clinical drug development program: examples from a heart failure program. [PDF]
, 2016 BackgroundPatient-reported outcome (PRO) measures can be used to support label claims if they adhere to US Food & Drug Administration guidance. The process of developing a new PRO measure is expensive and time-consuming.
Anatchkova, Milena +8 more
core +1 more source
Health and Quality of Life Outcomes, 2018 BackgroundInterpretation of differences or changes in patient-reported outcome scores should not only consider statistical significance, but also clinical relevance.
Ahmad Ousmen +8 more
semanticscholar +1 more source
Patient reported outcomes [PDF]
European Journal of Cardiovascular Nursing, 2015 David Morley, Crispin Jenkinson
openaire +2 more sources
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source
Patient-reported outcome measures v. clinician-measured outcomes in community psychiatric practice [PDF]
, 2012 Aims and method We examine the feasibility of the routine use of three patient-reported and one clinician-rated outcome measures (patient-identified problem, EuroQol-5D questionnaire, EuroQol Visual Analogue Scale and Health of the Nation Outcome Scales
Cope, D. +4 more
core +1 more source
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source
Group 3 ITI Consensus Report: Patient‐reported outcome measures associated with implant dentistry
Clinical Oral Implants Research, 2018 OBJECTIVES The aim of Working Group 3 was to focus on three topics that were assessed using patient-reported outcome measures (PROMs). These topics included the following: (a) the aesthetics of tooth and implant-supported fixed dental prostheses focusing
J. Feine +29 more
semanticscholar +1 more source