Results 121 to 130 of about 2,917,465 (307)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Individual Nurse Productivity in Preparing Patients for Discharge Is Associated with Patient Likelihood of 30-Day Return to Hospital [PDF]

Objective: Applied to value-based health care, the economic term “individual productivity” refers to the quality of an outcome attributable through a care process to an individual clinician.
Bang, James, Bobay, Kathleen L., Buerhaus, Peter I., Costa, Linda L., Hamilton, Morris, Hughes, Ronda G., Weiss, Marianne E., Yakusheva, Olga   +7 more
core  

Structured review of the patient-reported outcome instruments used in clinical trials in head and neck surgery [PDF]

The number of clinical trials that relate to patients with cancer of the head and neck is growing. Patient-reported outcomes, which are rarely the primary outcome, are now an important component, and in this structured review to identify and report the ...
Barraclough, J, Boyes, H, Kanatas, A, Ratansi, R, Rogers, SN   +4 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Are TKA kinematics during closed kinetic chain exercises associated with patient-reported outcomes? A preliminary analysis [PDF]

BackgroundKinematic patterns after TKA can vary considerably from those of the native knee. It is unknown, however, if there is a relationship between a given kinematic pattern and patient satisfaction after TKA.Questions/purposesIs there an association ...
Van Der Straeten, Catherine, Van Eenoo, Wies, Van Onsem, Stefaan, Verstraete, Matthias, Victor, Jan   +4 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Adoption of electronic patient-reported outcomes in cancer clinical practice: the point of view of Italian patients

ESMO Real World Data and Digital Oncology
Background: In 2022, the European Society for Medical Oncology (ESMO) guideline recommended the adoption of electronic patient-reported outcomes measures (ePROMs) in routine clinical practice for patients with cancer.
A.A. Valsecchi, V. Battista, S. Terzolo, R. Dionisio, G. Lacidogna, D. Marino, V. Quarà, E. Sperti, V. Tuninetti, F. Vignani, C. Zichi, V.E. Bounous, G. Valabrega, A. Ferrero, N. Biglia, M. Di Maio   +15 more
doaj   +1 more source

Monovision LASIK in emmetropic presbyopic patients. [PDF]

BackgroundTo evaluate the efficacy and patient satisfaction of laser in situ keratomileusis (LASIK) monovision correction in presbyopic emmetropic patients.MethodsA retrospective review of 294 patients who underwent LASIK for monovision was conducted ...
Hannan, Stephen, Peng, Michelle Y, Schallhorn, Julie M, Schallhorn, Steven J, Teenan, David   +4 more
core  

The impact of culturally competent diabetes care interventions for improving diabetes-related outcomes in ethnic minority groups : a systematic review [PDF]

Aim  To examine the evidence on culturally competent interventions tailored to the needs of people with diabetes from ethnic minority groups. Methods  MEDLINE (NHS Evidence), CINAHL and reference lists of retrieved papers were searched from inception ...
Cannaby, A. M., Sandhu, Harbinder, Sturt, Jackie, Zeh, Peter   +3 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source