Results 131 to 140 of about 1,808,242 (260)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Cross-cultural adaptation of the Italian Chronic Rhinosinusitis Patient-Reported Outcome. Questionnaire. [PDF]

Acta Otorhinolaryngol Ital
Maniaci A, Locatello LG, Fadda GL, Boscolo-Rizzo P, De Corso E, Lechien JR, Calvo-Henriquez C, Sowerby LJ, Saibene AM.   +8 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Case Series: Can Daily Patient-Reported Outcome Measures Be Implemented for Cancer-Related Fatigue? [PDF]

Cancer Rep (Hoboken)
Tilg A, Meryk A, Weiss JG, Crazzolara R.
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Can Patient-Reported Outcome Measures Help Predict Unplanned Hospital Readmission? [PDF]

Med Care
Yu M, Harrison M, Wong H, Trenaman L, Bryan S, Lix L, Sawatzky R, Cuthbertson L, Al Sayah F, Bansback N.   +9 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Development and validation of PEYRO-Q: a novel multidimensional patient-reported outcome measure for Peyronie's disease. [PDF]

Sex Med
Cocci A, Lo Re M, Pezzoli M, Romero-Otero J, Salamanca JIM, Mourel-Journel N, Neuville P, Faix A, Ward S, Van Renterghem K, Hatzichristodoulou G, Osmonov D, Ralph D, Cadenar A, Falcone M, Russo GI, Bettocchi C, Cacciamani GE, Mondaini N, Skrodzka M, Pozzi E, Salonia A.   +21 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Multicentre validation of a patient-reported outcome measure for functional movement disorders. [PDF]

J Neurol Neurosurg Psychiatry
Michaelis R, Hagedorn L, Weissbach A, van Riesen C, Zeuner KE, Schmidt T, Bolte C, Bernsdorff F, Löw MJ, Gless CA, Reincke A, Sykora D, LaFaver K, Lehn AC, Kleinschnitz C, Seliger C, Popkirov S.   +16 more
europepmc   +1 more source