Results 101 to 110 of about 2,917,465 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Completeness of repeated patient-reported outcome measures in adult rehabilitation: a randomized controlled trial in a diverse clinical population

BMC Health Services Research
Background Data collection through patient-reported outcome measures (PROMs) is essential for the purpose of rehabilitation research and registries. Existing problems with incomplete PROM data may relate to the patient burden and data set length.
Anne-Lene Sand-Svartrud, Ingvild Kjeken, Renate Foss Skardal, Gunhild M. Gjerset, Tonje Jossie Johnsen, Anne Dorte Lyken, Hanne Dagfinrud, Rikke Helene Moe   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Clinical Symptom Profiles After Mild–Moderate Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background There is heterogeneity in the severity of domains affected in patients with stroke, resulting in differences in health‐related quality of life (hrQoL).
Irene L. Katzan, Andrew Schuster, Mark Bain, Brittany Lapin   +3 more
doaj   +1 more source

Patient reported outcome and experience measures of oral disease in oral medicine [PDF]

A recent meeting of health ministers from over 40 countries worldwide deemed that time and money should be spent on outcome and experience measures that would allow us to determine whether our health systems deliver outcomes that truly matter to patients.
Ni Riordain, R, Wiriyakijja, P
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Patient-reported outcome, clinician-reported outcome, and patient satisfaction with treatment by crisis resolution teams: a multicenter pre-post study of outcome and associated factors in Norway

BMC Psychiatry
Background Crisis resolution teams (CRTs) have become a part of mental health services in many high-income countries. Many studies have investigated the impact of CRTs on acute admissions to inpatient units, but very few studies have investigated patient-
T. Ruud, N. Hasselberg, J. Siqveland, K. H. Holgersen   +3 more
doaj   +1 more source

Systematic review of patient-reported outcome measures in patients with varicose veins. [PDF]

BACKGROUND: Varicose veins can affect quality of life. Patient-reported outcome measures (PROMs) provide a direct report from the patient about the impact of the disease without interpretation from clinicians or anyone else.
Beebe-Dimmer, Brazier, Chen, Department of Health, Deyo, Digital, Evans, Fayers, Fitzpatrick, Food and Drug Administration, Francis, Garratt, Garratt, Garratt, Garratt, Guyatt, Guyatt, Kline, Lamping, Lattimer, Lattimer, Liberati, Maurins, McKenna, Michaels, Michaels, Mokkink, Morris, National Clinical Guideline Centre, Nijsten, Nunnally, Patrick, Paty, Poku, Shepherd, Terwee, What quality of life? The WHOQOL Group, Wright, Zimmerman   +38 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Communicating prognostic uncertainty in potential end-of-life contexts: experiences of family members [PDF]

Background: This article reports on the concept of “communicating prognostic uncertainty” which emerged from a mixed methods survey asking family members to rank their satisfaction in seven domains of hospital end-of-life care. Methods: Open-ended
Gallagher, Romayne, Krawczyk, Marian
core   +1 more source