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Patient-reported outcome measurement [PDF]
Journal of the Royal Society of Medicine, 2010 Alan Maynard and Karen Bloor1 raise interesting questions, particularly in relation to breast cancer. One issue is that treatment-related toxicities may not become problematic for several years, particularly when radiotherapy is administered. Research so far seems to indicate that hypofractionation causes more long-term problems than hyperfractionation,
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Self-reported Mental Disorders Negatively Influence Surgical Outcomes After Arthroscopic Treatment of Femoroacetabular Impingement. [PDF]
, 2018 Background:Femoroacetabular impingement (FAI) is responsible for hip pain and dysfunction, and surgical outcomes depend on multiple factors. The presence of mental disorders negatively influences outcomes of multiple orthopaedic conditions, although the ...
Harris, Joshua D +4 more
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Patient-reported outcome measures [PDF]
Journal of the Royal Society of Medicine, 2007 In their recent essay (JRSM 2007;100:306-8), Maynard & Ayalew referred to the absence of patient reported outcome measures (PROM). They should have been aware that the Royal College of Surgeons of England, with the London School of Hygiene and Tropical Medicine, carried out a project to establish the feasibility of applying PROM for elective surgical ...
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Incorporating development of a patient-reported outcome instrument in a clinical drug development program: examples from a heart failure program. [PDF]
, 2016 BackgroundPatient-reported outcome (PRO) measures can be used to support label claims if they adhere to US Food & Drug Administration guidance. The process of developing a new PRO measure is expensive and time-consuming.
Anatchkova, Milena +8 more
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Patient reported outcomes in orthopaedics [PDF]
Journal of Orthopaedic Research, 2017 ABSTRACTPatient reported outcome measures (PROMs) are key tools when performing clinical research and PROM data are increasingly used to inform clinical decision‐making, patient‐centered care, health policy and more recently, reimbursement decisions. PROMs must possess particular properties before they are used. Thus purpose of this paper is to give an
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Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Consistent Patient-Reported Outcomes
Value in Health, 2002 Health-related quality of life (HRQL) measures extend patient outcome assessment beyond survival, adverse effects, and clinical efficacy, and reflect the patient’s perspective on the impact of disease and its treatment on functioning and wellbeing. An important objective for evaluating HRQL outcomes is to demonstrate the value of new pharmaceutical ...
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FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
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Patient-reported outcome measures v. clinician-measured outcomes in community psychiatric practice [PDF]
, 2012 Aims and method We examine the feasibility of the routine use of three patient-reported and one clinician-rated outcome measures (patient-identified problem, EuroQol-5D questionnaire, EuroQol Visual Analogue Scale and Health of the Nation Outcome Scales
Cope, D. +4 more
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FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source