Results 291 to 300 of about 7,676,849 (387)

Patient-Reported Outcome Measures in Safety Event Reporting: PROSPER Consortium Guidance [PDF]

, 2013

core   +1 more source

Reliability and validity of the Finnish version of the AO spine PROST (patient reported outcome spine trauma). [PDF]

J Orthop Surg Res
Toivonen LA, Repo JP, Kautiainen H, Sadiqi S, Neva MH.   +4 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

A new generation of patient-reported outcome measures with large language models. [PDF]

J Patient Rep Outcomes
Terheyden JH, Pielka M, Schneider T, Holz FG, Sifa R.   +4 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

A COSMIN systematic review of generic patient-reported outcome measures in Switzerland. [PDF]

Qual Life Res
Elsener T, Kerry M, Biller-Andorno N.
europepmc   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Asthma self-knowledge patient-reported outcome measures for the paediatric population with asthma: a systematic review protocol. [PDF]

BMJ Open
Gonçalves AS, Simões PA, Gama JMR, Jácome C, Maricoto T.   +4 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

QL4 THE CONTENT VALIDITY OF CLINICIAN DERIVED PATIENT REPORTED OUTCOMES (PRO) MEASURES: THE ROLAND MORRIS DISABILITY QUESTIONNAIRE

, 2005
N. Horowicz-Mehler, Catherine Evans, Linda Abetz, C West, Catherine Copley‐Merriman   +4 more
openalex   +1 more source