Results 51 to 60 of about 2,675,009 (295)

Patient-Reported Outcome of Physical Therapy in Amyotrophic Lateral Sclerosis: Observational Online Study [PDF]

, 2018
Background: Physical therapy is an essential component of multidisciplinary treatment in amyotrophic lateral sclerosis (ALS). However, the meaning of physical therapy beside preservation of muscular strength and functional maintenance is not fully ...
Funke, Andreas, Kettemann, Dagmar, Maier, André, Meyer, Robert, Meyer, Thomas, Münch, Christoph, Spittel, Susanne, Steinfurth, Laura   +7 more
core   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Integration of patient-reported outcome measures with key clinical outcomes after immediate latissimus dorsi breast reconstruction and adjuvant treatment

, 2013
Background: linical evidence on patient-reported outcome measures (PROMS) in breast reconstruction is lacking. The aim of this study was to evaluate PROMs in implant-assisted latissimus dorsi (LDI) or tissue-only autologous latissimus dorsi (ALD) flap ...
Balta, V, Benson, J, Betambeau, N, Haviland, J, Prospective Trial Management, Grp, Reece-Smith, A, Winters, Z. E   +6 more
core   +1 more source

Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative) [PDF]

, 2016
This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmö, Sweden on 23–24 April 2015 (HOME IV).
Abuabara, K., Aoki, V., Apfelbacher, C.J., Ardeleanu, M., Awici-Rasmussen, M., Barbarot, S., Berents, T.L., Bjerring Clemmensen, K.K., Block, J., Bragg, A., Burton, T., Chalmers, J.R., Creswell-Melville, A., Dinesen, M., Drucker, A., Eckert, L., Flohr, C., Garg, M., Gerbens, L.A.A., Graff, A.L.B., Hanifin, J., Heinl, D., Humphreys, R., Ishii, H.A., Kataoka, Y., Leshem, Y.A., Marquort, B., Massuel, M.-A., Merhand, S., Mizutani, H., Murota, H., Murrell, D.F., Nakahara, T., Nasr, I., Nograles, K., Ohya, Y., Osterloh, I., Pander, J., Prinsen, C., Purkins, L., Ridd, M., Sach, T., Schmitt, J., Schuttelaar, M.-L. A., Shindo, S., Simpson, E., Singh, J.A., Smirnova, J., Spuls, P.I., Sulzer, A., Svensson, Å., Synnøve Gjerde, E., Takaoka, R., Tauber, M., Thomas, K.S., Torchet, F., Vestby Talmo, H., Volke, A., von Kobyletzki, L., Wahlgren, C.-F., Weidinger, S., Weisshaar, E., Williams, H.C., Wollenberg, A., Yamaga, K., Zhao, C.Y.   +65 more
core   +3 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Modern psychometrics applied in rheumatology - a systematic review [PDF]

, 2011
Background Although item response theory (IRT) appears to be increasingly used within health care research in general, a comprehensive overview of the frequency and characteristics of IRT analyses within the rheumatic field is lacking. An overview of the
Glas, C.A.W., Klooster, P.M. ten, Laar, M.A.F.J. van de, Siemons, L., Taal, E.   +4 more
core   +4 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Physical Function and Quality of Life After Resection of Mobile Spine Chondrosarcoma. [PDF]

, 2019
Study Design:Retrospective cohort study. Objectives:(1) To assess patient-reported outcomes-physical function, pain, and quality of life-in patients who underwent resection of a mobile spine chondrosarcoma.
Chen, Yen-Lin E, DeLaney, Thomas F, Hartveldt, Stefan, Hornicek, Francis J, Janssen, Stein J, Paulino Pereira, Nuno Rui, Schwab, Joseph H, Stoop, Nicky   +7 more
core   +1 more source

Patient-Reported Outcomes: Conceptual Issues

Value in Health, 2007
There is a broad agreement that patient-reported outcome (PRO) assessment in health care should proceed from a strong conceptual basis, with rationales clearly articulated in advance concerning what is to be measured and how this is to be accomplished.
Philippe Beltran, Joseph Lipscomb, Joseph C. Cappelleri, Bonnie Teschendorf, Margaret Rothman   +4 more
openaire   +2 more sources