Results 61 to 70 of about 2,675,009 (295)

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

a protocol for developing a patient-reported outcome measurement instrument [PDF]

, 2016
Introduction: There is no consensus about what constitutes the most appropriate patient-reported outcome measurement (PROM) instrument for measuring physical function in patients with rheumatic hand conditions.
Bliddal, Henning, Christensen, Robin, Gershon, Richard, Haugen, Ida K., Henriksen, Marius, Kjeken, Ingvild, Klokker, Louise, Kloppenburg, Marg, Liegl, Gregor, Nolte, Sandra, Schalet, Ben, Terwee, Caroline B., Waehrens, Eva Ejlersen, Westhoven, Rene, Wittoek, Ruth   +14 more
core   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Patient-reported outcome measures for cancer caregivers: a systematic review [PDF]

, 2016
Purpose Informal caregivers provide invaluable help and support to people with cancer. As treatments extend survival and the potential burdens on carers increase, there is a need to assess the impact of the role.
A Girgis, A Girgis, A Lafaye, B Cooper, BA Given, BR Ferrell, BS Fletcher, C Nijboer, CW Given, DW Sherman, EK Grov, ER Giovannetti, G Can, IJ Higginson, JF Deeken, JI Cameron, KJ McKee, Lesley Fallowfield, LL Northouse, Lucy Matthews, M Glajchen, M Glajchen, M Stommel, MA Weitzner, MA Weitzner, MA Weitzner, MT Oberst, P Minaya, PJ Haylock, R Cohen, R Fitzpatrick, R Lazarus, RC Macefield, RE Stein, S Khanjari, S Schur, SD Lambert, SH Zarit, SH Zarit, U Stenberg, Valerie Jenkins, Valerie Shilling, WB Brouwer, WB Brouwer, Y Kim, YG Bachner, YS Rhee   +46 more
core   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

The impact of culturally competent diabetes care interventions for improving diabetes-related outcomes in ethnic minority groups : a systematic review [PDF]

, 2012
Aim  To examine the evidence on culturally competent interventions tailored to the needs of people with diabetes from ethnic minority groups. Methods  MEDLINE (NHS Evidence), CINAHL and reference lists of retrieved papers were searched from inception ...
Cannaby, A. M., Sandhu, Harbinder, Sturt, Jackie, Zeh, Peter   +3 more
core   +1 more source

Patient-reported outcomes in psychiatry

Dialogues in Clinical Neuroscience, 2014
The recent trend for recognizing the need that patients actively participate in the assessment of the outcome of treatment is a welcome development, not only because it adds valuable data, but also because its recognition of the partnership role that the patients should have in research on outcome of mental illness.
openaire   +3 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Patient-reported outcomes 6 months after enhanced recovery after colorectal surgery. [PDF]

, 2018
BackgroundEnhanced recovery after surgery (ERAS) programs have been established as perioperative strategies associated with improved outcomes. However, intermediate and long-term patient-reported outcome data for patients undergoing ERAS interventions ...
Chen, Lee-Lynn, Deiss, Thomas, Naidu, Ramana K, Sarin, Ankit   +3 more
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