Results 71 to 80 of about 2,863,004 (297)

Parent‐to‐Child Information Disclosure in Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite professional consensus regarding the importance of open communication with pediatric cancer patients about their disease, actual practice patterns of disclosure are understudied. Extant literature suggests a significant proportion of children are not told about their diagnosis/prognosis, which is purported to negatively ...
Rachel A. Kentor, Flora Hoodin, Michelle Byrd, Kristin A. Kullgren, Leah LaLonde, Lauren Benkoske, Patrick Smith, Dawn Carson, Karen MacDonald, Susumu Inoue, Brenda Kitchen, Kate Gowans, Gregory A. Yanik   +12 more
wiley   +1 more source

Communicating prognostic uncertainty in potential end-of-life contexts: experiences of family members [PDF]

, 2016
Background: This article reports on the concept of “communicating prognostic uncertainty” which emerged from a mixed methods survey asking family members to rank their satisfaction in seven domains of hospital end-of-life care. Methods: Open-ended
Gallagher, Romayne, Krawczyk, Marian
core   +2 more sources

A qualitative reflexive thematic analysis of innovation and regulation in hearing health care

BMC Medicine
Background The hearing health sector is an example of a health sector that is experiencing a period of rapid innovation driven by digital technologies.
Isabelle Boisvert, Samantha Cruz Rivera, Jennifer Smith-Merry, Barbara Molony-Oates, Emily Kecman, Sarah E. Hughes   +5 more
doaj   +1 more source

Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension

The Lancet: Digital Health, 2020
Summary: The SPIRIT 2013 statement aims to improve the completeness of clinical trial protocol reporting by providing evidence-based recommendations for the minimum set of items to be addressed.
Samantha Cruz Rivera, PhD, Xiaoxuan Liu, MBChB, An-Wen Chan, MD, Alastair K Denniston, ProfPhD, Melanie J Calvert, ProfPhD, Hutan Ashrafian, Andrew L Beam, Gary S Collins, Ara Darzi, Jonathan J Deeks, M Khair ElZarrad, Cyrus Espinoza, Andre Esteva, Livia Faes, Lavinia Ferrante di Ruffano, John Fletcher, Robert Golub, Hugh Harvey, Charlotte Haug, Christopher Holmes, Adrian Jonas, Pearse A Keane, Christopher J Kelly, Aaron Y Lee, Cecilia S Lee, Elaine Manna, James Matcham, Melissa McCradden, David Moher, Joao Monteiro, Cynthia Mulrow, Luke Oakden-Rayner, Dina Paltoo, Maria Beatrice Panico, Gary Price, Samuel Rowley, Richard Savage, Rupa Sarkar, Sebastian J Vollmer, Christopher Yau   +39 more
doaj   +1 more source

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Measure selection for an electronic patient-reported outcome (ePRO) system for CAR T-cell therapy patients: a modified Delphi consensus studyResearch in context

EClinicalMedicine
Summary: Background: Chimeric Antigen Receptor (CAR) T-cell therapies are effective for treating haematological cancers but carry risks of toxicity and substantial symptom burden.
Sarah E. Hughes, Foram Khatsuria, Christel McMullan, Karen L. Shaw, Anita Walker, Francesca Kinsella, David Burns, Olalekan L. Aiyegbusi, Elin Haf Davies, John Ansell, Evelyn Chakera, Charles Craddock, Alastair Denniston, Rebecca Lloyd, Paul Ferguson, Ronjon Chakraverty, Melanie Calvert   +16 more
doaj   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Patient-Reported Outcome of Physical Therapy in Amyotrophic Lateral Sclerosis: Observational Online Study [PDF]

, 2018
Background: Physical therapy is an essential component of multidisciplinary treatment in amyotrophic lateral sclerosis (ALS). However, the meaning of physical therapy beside preservation of muscular strength and functional maintenance is not fully ...
Funke, Andreas, Kettemann, Dagmar, Maier, André, Meyer, Robert, Meyer, Thomas, Münch, Christoph, Spittel, Susanne, Steinfurth, Laura   +7 more
core   +1 more source

An investigation of methods to improve recall for the patient-reported outcome measurement in COPD patients: a pilot randomised control trial and feasibility study protocol

Pilot and Feasibility Studies, 2019
Background Patient-reported outcomes (PRO) are used to measure the effectiveness of interventions for management of chronic conditions such as chronic obstructive pulmonary disease.
Sheree M. S. Smith, Stephen Jan, Joseph Descallar, Guy B. Marks   +3 more
doaj   +1 more source

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source