Results 71 to 80 of about 6,736,971 (342)

Does scrolling affect measurement equivalence of electronic patient-reported outcome measures (ePROM)? Results of a quantitative equivalence study

Journal of Patient-Reported Outcomes, 2021
Background Scrolling is a perceived barrier in the use of bring your own device (BYOD) to capture electronic patient reported outcomes (ePROs). This study explored the impact of scrolling on the measurement equivalence of electronic patient-reported ...
Saeid Shahraz, Tan P. Pham, Marc Gibson, Marie De La Cruz, Munther Baara, Sachin Karnik, Christopher Dell, Sheryl Pease, Suyash Nigam, Joseph C. Cappelleri, Craig Lipset, Patrick Zornow, Jeff Lee, Bill Byrom   +13 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Extending the Range of Measurement for Minimally Invasive Treatments by Adding New Concepts to FACE-Q Aesthetics Scales

Plastic and Reconstructive Surgery, Global Open
Background:. The Satisfaction with Face Overall and Psychological Function scales are the most frequently used FACE-Q Aesthetics module scales. This study aimed to extend their range of measurement by adding and testing new concepts.
Anne F. Klassen, DPhil, Andrea L. Pusic, MD, Manraj Kaur, PhD, Charlene Rae, PhD, Lotte Poulsen, MD, PhD, Jasmine Mansouri, BSc, Elena Tsangaris, PhD, Steven Dayan, MD, Jennifer Klok, MD, Kathleen Armstrong, MD, Katherine Santosa, MD, Stefan Cano, PhD, CPsychol, AFBPsS   +11 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Added Value of Patient‐Reported Outcome Measures in Stroke Clinical Practice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThere is uncertainty regarding the clinical utility of the data obtained from patient‐reported outcome measures (PROMs) for patient care. We evaluated the incremental information obtained by PROMs compared to the clinician‐reported modified ...
Irene L. Katzan, Nicolas R. Thompson, Brittany Lapin, Ken Uchino   +3 more
doaj   +1 more source

Patient-Reported Outcomes in Cardiothoracic Surgery [PDF]

The Annals of Thoracic Surgery, 2019
Current studies in cardiothoracic clinical research frequently fail to use end points that are most meaningful to patients, including measures associated with quality of life. Patient-reported outcomes (PROs) represent an underused but important component of high-quality patient-centered care.
Subramanian, Melanie, Kozower, Benjamin D, Brown, Lisa M, Khullar, Onkar V, Fernandez, Felix G   +4 more
openaire   +5 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Protocol for a mixed-methods study to develop and feasibility test a digital system for the capture of patient-reported outcomes (PROs) in patients receiving chimeric antigen receptor T-cell (CAR-T) therapies (the PRO-CAR-T study)

BMJ Open
Introduction Chimeric antigen receptor (CAR) T-cell therapies are novel, potentially curative therapies for haematological malignancies. CAR T-cell therapies are associated with severe toxicities, meaning patients require monitoring during acute and ...
Christel McMullan, Melanie Calvert, Karen Shaw, Sarah E Hughes, Olalekan Lee Aiyegbusi, Elin Haf Davies, Charles Craddock, David Burns, Francesca Kinsella, Paul Ferguson, Foram Khatsuria, Lester Pyatt, John Ansell, Evelyn Chakera, Julie Richardson-Abraham   +14 more
doaj   +1 more source

Patients reported outcomes in thoracic surgery [PDF]

Journal of Thoracic Disease, 2018
Recent advances in early detection and targeted therapies of lung cancer have contributed to improve prognosis. In this context, the importance of preserving quality of life (QOL) of lung cancer survivors is compounded.
Pompili, C, Absolom, K, Velikova, G, Backhus, L   +3 more
openaire   +3 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source