Results 81 to 90 of about 6,736,971 (342)

Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension

The Lancet: Digital Health, 2020
Summary: The SPIRIT 2013 statement aims to improve the completeness of clinical trial protocol reporting by providing evidence-based recommendations for the minimum set of items to be addressed.
Samantha Cruz Rivera, PhD, Xiaoxuan Liu, MBChB, An-Wen Chan, MD, Alastair K Denniston, ProfPhD, Melanie J Calvert, ProfPhD, Hutan Ashrafian, Andrew L Beam, Gary S Collins, Ara Darzi, Jonathan J Deeks, M Khair ElZarrad, Cyrus Espinoza, Andre Esteva, Livia Faes, Lavinia Ferrante di Ruffano, John Fletcher, Robert Golub, Hugh Harvey, Charlotte Haug, Christopher Holmes, Adrian Jonas, Pearse A Keane, Christopher J Kelly, Aaron Y Lee, Cecilia S Lee, Elaine Manna, James Matcham, Melissa McCradden, David Moher, Joao Monteiro, Cynthia Mulrow, Luke Oakden-Rayner, Dina Paltoo, Maria Beatrice Panico, Gary Price, Samuel Rowley, Richard Savage, Rupa Sarkar, Sebastian J Vollmer, Christopher Yau   +39 more
doaj   +1 more source

The facilitators and barriers to implementing patient reported outcome measures in organisations delivering health related services: a systematic review of reviews

Journal of Patient-Reported Outcomes, 2018
BackgroundThere is increasing interest in using Patient Reported Outcome Measures (PROMs) within organisations delivering health related services. However, organisations have had mixed success in implementing PROMs and there is little understanding about
Alexis Foster, L. Croot, J. Brazier, Janet Harris, A. O’Cathain   +4 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Patient-Reported Outcome Measures in Atopic Dermatitis and Chronic Hand Eczema in Adults

Patient, 2019
Patient-reported outcome measures (PROMs) provide an important complement to physician-assessed clinical outcome measures in dermatologic diseases such as atopic dermatitis (AD) and chronic hand eczema (CHE).
A. Barrett, Julie Hahn-Pedersen, Nana Kragh, E. Evans, A. Gnanasakthy   +4 more
semanticscholar   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Patient information role in integrated health care

International Journal of Integrated Care, 2019
Background: Integrated patient-centered care is a call for fundamental shift in how health care services are delivered as it is believed to improve patient outcomes and experience. Patient-Reported Outcome Measures (PROMs) and Patient Reported Experience
José M Quintana, Maria João Forjaz, Itziar Vergara, Juan Manuel Ramos-Goñi, Noemí Robles, Antonio Sarría-Santamera   +5 more
doaj   +1 more source

Orthopaedic registries with patient-reported outcome measures

EFORT Open Reviews, 2019
Total joint arthroplasty is performed to decreased pain, restore function and productivity and improve quality of life. One-year implant survivorship following surgery is nearly 100%; however, self-reported satisfaction is 80% after total knee ...
I. Wilson, E. Bohm, A. Lübbeke, S. Lyman, S. Overgaard, O. Rolfson, A. W-Dahl, M. Wilkinson, M. Dunbar   +8 more
semanticscholar   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

A qualitative reflexive thematic analysis of innovation and regulation in hearing health care

BMC Medicine
Background The hearing health sector is an example of a health sector that is experiencing a period of rapid innovation driven by digital technologies.
Isabelle Boisvert, Samantha Cruz Rivera, Jennifer Smith-Merry, Barbara Molony-Oates, Emily Kecman, Sarah E. Hughes   +5 more
doaj   +1 more source

Development of the pediatric daily ulcerative colitis signs and symptoms scale (DUCS): qualitative research findings

BMC Research Notes, 2017
Background The purpose of this study is to develop patient-reported (PRO) and observer-reported (ObsRO) outcome measures of ulcerative colitis (UC) signs/symptoms in children aged 5–17 with mild/moderate UC.
Emuella Flood, Debra G. Silberg, Beverly Romero, Kathleen Beusterien, M. Haim Erder, Carmen Cuffari   +5 more
doaj   +1 more source