Results 91 to 100 of about 2,966,345 (343)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

A systematic review of weight-related communication trainings for physicians: What do we know and how can we inform future development of training programs? [PDF]

, 2017
It is reported that physicians lack training to address weight-related concerns with patients. To overcome this, training programs have been implemented in medical settings to prepare physicians to have conversations with patients. However, it is unclear
LaRose, Jessica G, Reading, Jean M, Snell, Morgan   +2 more
core   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Evaluating methodological quality of Prognostic models Including Patient-reported HeAlth outcomes in oncologY (EPIPHANY): A systematic review protocol [PDF]

, 2018
Introduction While there is mounting evidence of the independent prognostic value of patient-reported outcomes (PROs) for overall survival (OS) in patients with cancer, it is known that the conduct of these studies may hold a number of methodological ...
Anota, Amélie, Collins, Gary S., Cottone, Francesco, Deliu, Nina, Efficace, Fabio   +4 more
core   +2 more sources

Patient-Reported Outcomes: Conceptual Issues

Value in Health, 2007
There is a broad agreement that patient-reported outcome (PRO) assessment in health care should proceed from a strong conceptual basis, with rationales clearly articulated in advance concerning what is to be measured and how this is to be accomplished.
Philippe Beltran, Joseph Lipscomb, Joseph C. Cappelleri, Bonnie Teschendorf, Margaret Rothman   +4 more
openaire   +2 more sources

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

The Establishment of the GENEQOL Consortium to Investigate the Genetic Disposition of Patient-Reported Quality-of-Life Outcomes [PDF]

To our knowledge, no comprehensive, interdisciplinary initiatives have been taken to examine the role of genetic variants on patient-reported quality-of-life outcomes.
Charles S. Cleeland, Jeff A. Sloan, Michele Y. Halyard, Mirjam A. G. Sprangers, Ruut Veenhoven   +4 more
core  

The establishment of the GENEQOL consortium to investigate the genetic disposition of patient-reported quality-of-life outcomes [PDF]

, 2009
To our knowledge, no comprehensive, interdisciplinary initiatives have been taken to examine the role of genetic variants on patient-reported quality-of-life outcomes.
Ailko H. Zwinderman, Amy P. Abertnethy, Amylou C. Dueck, Andrea M. Barsevick, Benjamin Movsas, Bower J. E., Cella D. F., Charles S. Cleeland, Christine Miaskowski, Cornelis J. F. Van Noorden, Cynthia Chauhan, Donald L. Patrick, Dorret I. Boomsma, Frank Baas, Gen Shinozaki, Jasvinder A. Singh, Jeff A. Sloan, Johnson W., Marlene H. Frost, Mary E. Ropka, Meike Bartels, Michele Y. Halyard, Miriam Mosing, Mirjam A. G. Sprangers, Mock V., Nancy L. Pedersen, Nicholas G. Martin, Per Hall, Ping Yang, Pål Klepstad, Quiling Shi, Rich T. A., Romeis J. C., Ruut Veenhoven, Svardh C., Svedberg P., Svedberg P., Yang P.   +37 more
core   +5 more sources

Perfect health not so perfect after all – a methodological study on patient-reported outcome measures in 2574 patients following percutaneous coronary intervention

Health and Quality of Life Outcomes
Background Patient-reported outcome measures (PROMs) are crucial to capture patients’ health and illness status. Selecting the most suitable PROM to measure self-reported health in a specific study population is essential.
T. M. Norekvål, M. M. Iversen, K. Oterhals, H. Allore, B. Borregaard, T. R. Pettersen, D. R. Thompson, A. D. Zwisler, K. Breivik   +8 more
doaj   +1 more source

Development of a risk prediction score for screening for HBV, HCV and HIV among migrants in France: results from a multicentre observational study (STRADA study)

BMJ Open
Objectives Migrants from high HIV, hepatitis B virus (HBV) or hepatitis C virus (HCV) endemicity regions have a great burden of these infections and related diseases in the host countries.
Issifou Yaya, France Lert, Françoise Roudot-Thoraval, Olivier Chassany, David Zucman, Frédérique Thonon, Martin Duracinsky, Lisa Yombo-Kokule, Pascal Bessonneau, Olivia Rousset-Torrente   +9 more
doaj   +1 more source