Results 231 to 240 of about 6,836,441 (345)

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Patient-reported outcomes for remote and in-person visits for genetic counseling in adult neurology. [PDF]

J Genet Couns
Paul RA, Babaian N, Brzozowski M, Baldwin A, Johnson K, Azage M, Bardakjian T, Tropea TF, Dratch L.   +8 more
europepmc   +1 more source

Effect of patient characteristics on reported outcomes after total knee replacement [PDF]

, 2006
Antonio Escobar, José M. Quintana, Amaia Bilbao, Jesús Azkárate, José Ignacio Güenaga, Juan Carlos Arenaza, Luis‐Felipe Gutiérrez   +6 more
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Longitudinal deteriorations in patient reported outcomes in patients with COPD [PDF]

, 2006
Toru Oga, Koichi Nishimura, Mitsuhiro Tsukino, Susumu Satô, Takashi Hajiro, Michiaki Mishima   +5 more
openalex   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Validity and Reliability of Clinical and Patient-Reported Outcomes in Multisystem Proteinopathy 1. [PDF]

Ann Clin Transl Neurol
Alfano LN, Iammarino MA, Reash NF, Lowes LP, Pietruszewski L, Adderley K, Humphrey L, Knight AB, Steiner CL, Smith MA, Sahenk Z, Connolly AM, Almomen M, D'Ambrosio ES, Peck N, Peck A.   +15 more
europepmc   +1 more source

The Translation and Cultural Adaptation of Patient-Reported Outcome Measures

, 2005
Stephen P. McKenna, Lynda Doward
openalex   +1 more source

The impact of the Calman–Hine report on the processes and outcomes of care for Yorkshire's colorectal cancer patients [PDF]

, 2006
Eva Morris, Raymond Haward, Mark S. Gilthorpe, Cheryl Craigs, D Forman   +4 more
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source