Results 211 to 220 of about 3,181,219 (306)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Patient-reported outcome measures in emergency and acute care: looking beyond the emergency room [PDF]

Clinical and Experimental Emergency Medicine
Jason B. Liu, David W. Bates
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Patient-reported outcomes: active surveillance vs radical therapies in low-risk prostate cancer. [PDF]

BJU Int
Al-Nader M, Kesch C, Mahmoud O, Hadaschik BA, Fichtner J, Carl G, Feick G, Burchardt M, Zimmermanns V, Prause L, Polat B, Blana A, Horstmann M, Saar M, Miglierini P, Almansur K, Hefermehl L, Porres D, Peters I, Wiens K, Palisaar RJ, Winter A, Neisius A, Kunzmann EM, Harke NN, Bolenz C, Albarghouth MH, Manka L, Kramer M, Luger F, Knoll T, Pfitzenmaier J, Brock M, Schittko J, Sommer JP, Reichert M, Lenart S, Huber P, Hijazi S, Calderaro A, Hermanns T, Tonhauser J, Kowalski C, Sibert NT.   +43 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Patient-reported outcomes during pregnancy and delivery in epidermolysis bullosa. [PDF]

BMC Pregnancy Childbirth
Zott A, Diem A, Prodinger C, Ude-Schoder K, Bauer JW, Welponer T, Laimer M.   +6 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Patient-reported outcomes after surgery for isolated radial head fractures: a systematic review. [PDF]

Arch Orthop Trauma Surg
Kumar N, Gabbe B, Page RS, Cosic F, Romero L, Heath E, Ackerman IN.   +6 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Hybrid Breast Reconstruction Revisited: Patient-Reported Outcomes Following Fat Grafting. [PDF]

J Clin Med
Pop IC, Muntean MV, Gata VA, Ilies RA, Nicoara D, Filip CI, Pop V, Achimas-Cadariu PA.   +7 more
europepmc   +1 more source