Results 201 to 210 of about 3,181,219 (306)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Which Total Knee Arthroplasty Revisions Do Not Improve Patient-Reported Outcomes? [PDF]

JB JS Open Access
Righolt CH, Poitras C, Hedden DR, Bohm ER, Turgeon TR.   +4 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Evaluation of a 10% Urea Lotion for Xerosis: Clinical and Patient-Reported Outcomes From a Prospective Study. [PDF]

J Cosmet Dermatol
Maletin N, Spasić B, Golušin Z, Binić I, Nišavić M, Ranđelović M, Golubović M, Borocki S, Marin L, Binić I, Denda N.   +10 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A practical evaluation of statistical methods for the analysis of patient reported outcomes in an observational pharmaceutical study. [PDF]

PLoS One
Williams LR, Marongiu A, Filippidis FT, Heinzkill M, van Troostenburg AR, Haubrich R, Ramroth H.   +6 more
europepmc   +1 more source

Expanding the Patient's Voice in Nephrology with Patient-Reported Outcomes. [PDF]

, 2019
Hays, Ron D, Peipert, John D
core   +1 more source

Digitization of Patient-Reported Outcomes [PDF]

Value in Health, 2013
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Reporting and Utilization of Patient-Reported Outcomes Measures in the Evaluation of Foot Orthoses Treatment: A Systematic Review. [PDF]

J Foot Ankle Res
Jiménez-Guillén J, Tovaruela-Carrión N, Moreno-Fresco MM, Martínez-Nova A, Munuera-Martínez PV.   +4 more
europepmc   +1 more source