Results 191 to 200 of about 3,181,219 (306)

Intermediate-term hip survivorship and patient-reported outcomes of periacetabular osteotomy: The Washington University Experience [PDF]

, 2018
Clohisy, John C, Duncan, Stephen, Goss, Charles W, Schoenecker, Perry, Thomason, Kayla, Wells, Joel   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Symptoms, side effects, quality of life and financial toxicity matter to patients with cancer, we need to do a better job of capturing and reporting these concepts in trials and clinical care

BMJ Oncology
Melanie Calvert, Roger Wilson, John Devin Peipert   +2 more
doaj   +1 more source

Factors influencing patient-reported outcomes in operatively managed tibial plateau fractures. [PDF]

Eur J Orthop Surg Traumatol
Alcaide D, Litten R, Krout JC, Hawkins G, Smitherman A, McIlwain R, McGwin G, Spitler C, Johnson J.   +8 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Patient-Reported Outcomes and Preferences for Total Hip Arthroplasty Approach-Crossover Cohort Study. [PDF]

J Clin Med
Skowronek P, Jankowski P, Czarzasta K, Kawka M.   +3 more
europepmc   +1 more source

Patient-Reported Outcomes, Patient-Reported Information

The Patient: Patient-Centered Outcomes Research
Baldwin, Mike, Spong, Andrew, Doward, Lynda, Gnanasakthy, Ari   +3 more
openaire   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Evaluation of patient-reported outcomes in coronary CT angiography versus invasive coronary angiography. [PDF]

Eur J Radiol Open
von der Stück MS, Siepmann R, Corban E, Frick M, Kuhl C, Dirrichs T.   +5 more
europepmc   +1 more source