Results 241 to 250 of about 6,836,441 (345)

Orchiectomy and scrotectomy as genital gender-affirming surgery: novel surgical technique and patient-reported outcomes. [PDF]

BMC Urol
Zoltin K, Shannon B, Timar R, Blasdel G, Shakir N.   +4 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

From checkboxes to emojis: a novel approach to patient-reported outcomes in multiple sclerosis. [PDF]

J Neurol
Neyal N, Krey KJ, Morrison HA, Nathoo N, Atkinson EJ, Son J, Flanagan EP, Pittock SJ, Uygunoglu U, Kantarci OH, Zeydan B.   +10 more
europepmc   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Patient-reported outcome measures in emergency and acute care: looking beyond the emergency room [PDF]

Clinical and Experimental Emergency Medicine
Jason B. Liu, David W. Bates
doaj   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Clinical Features and Patient-Reported Outcomes in a Cohort of Patients with Sjögren's Disease. [PDF]

J Clin Med
Izzetti R, Cinquini C, Fulvio G, Nisi M, Baldini C, Barone A.   +5 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Sex Differences in Clinical and Patient-Reported Outcomes in Transcatheter Aortic Valve Implantation: The TAVI-COMIC Trial. [PDF]

JACC Adv
Thevathasan T, Reitz F, Hornig C, Leistner DM, Dreger H, Sündermann S, Mattig I, Unbehaun A, Haghikia A, Skurk C, Hinkov H, Zirkelbach B, Stangl K, Falk V, Landmesser U, Hindricks G, Stangl V, Brand A.   +17 more
europepmc   +1 more source

QL4 THE CONTENT VALIDITY OF CLINICIAN DERIVED PATIENT REPORTED OUTCOMES (PRO) MEASURES: THE ROLAND MORRIS DISABILITY QUESTIONNAIRE

, 2005
N. Horowicz-Mehler, Catherine Evans, Linda Abetz, C West, Catherine Copley‐Merriman   +4 more
openalex   +1 more source