Results 61 to 70 of about 6,836,441 (345)

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Using patient-reported outcome measures to assess psychological well-being in a non-representative US general population during the COVID-19 pandemic

Journal of Patient-Reported Outcomes, 2022
Purpose The impact of the COVID-19 pandemic on psychological well-being will likely be long-lasting. Efforts directed towards monitoring the onset and progression of distress and mental health disorders are needed to identify and prioritize at-risk ...
Manraj N. Kaur, Elena Tsangaris, Tanujit Dey, Shelby Deibert, Janina Kueper, Maria Edelen, Andrea L. Pusic   +6 more
doaj   +1 more source

Patient outcomes, patient experiences and process indicators associated with the routine use of patient-reported outcome measures (PROMs) in cancer care: a systematic review

Supportive Care in Cancer, 2020
In current cancer care, there is a growing debate about the value of using patient-reported outcome measures (PROMs) in daily clinical follow-up. A systematic review of the literature was conducted to assess the evidence of the effectiveness of the ...
Caitlin Graupner, M. Kimman, S. Mul, A. Slok, D. Claessens, J. Kleijnen, C. Dirksen, S. Breukink   +7 more
semanticscholar   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Pruritus and Patient Reported Outcomes in Non-Dialysis CKD.

American Society of Nephrology. Clinical Journal, 2019
BACKGROUND AND OBJECTIVES Among patients on hemodialysis, pruritus has been associated with poorer mental and physical quality of life, sleep quality, depression, and mortality.
Nidhi Sukul, É. Speyer, Charlotte Tu, B. Bieber, Yun Li, A. Lopes, K. Asahi, L. Mariani, M. Laville, H. Rayner, B. Stengel, B. Robinson, R. Pisoni   +12 more
semanticscholar   +1 more source

Patient-Reported Outcomes in Cardiothoracic Surgery [PDF]

The Annals of Thoracic Surgery, 2019
Current studies in cardiothoracic clinical research frequently fail to use end points that are most meaningful to patients, including measures associated with quality of life. Patient-reported outcomes (PROs) represent an underused but important component of high-quality patient-centered care.
Subramanian, Melanie, Kozower, Benjamin D, Brown, Lisa M, Khullar, Onkar V, Fernandez, Felix G   +4 more
openaire   +5 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Patient-reported outcome measures for primary hyperparathyroidism: a systematic review of measurement properties

Health and Quality of Life Outcomes
Background The quality of patient-reported outcome measures (PROMs) used to assess the outcomes of primary hyperparathyroidism (PHPT), a common endocrine disorder that can negatively affect patients’ health-related quality of life due to chronic symptoms,
George Liang, Manraj N. Kaur, Carrie G. Wade, Maria O. Edelen, David W. Bates, Andrea L. Pusic, Jason B. Liu   +6 more
doaj   +1 more source

Patients reported outcomes in thoracic surgery [PDF]

Journal of Thoracic Disease, 2018
Recent advances in early detection and targeted therapies of lung cancer have contributed to improve prognosis. In this context, the importance of preserving quality of life (QOL) of lung cancer survivors is compounded.
Pompili, C, Absolom, K, Velikova, G, Backhus, L   +3 more
openaire   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source