Results 81 to 90 of about 6,836,441 (345)

Impact of Limited Health Literacy on Patient‐Reported Outcomes in Systemic Lupus Erythematosus

Arthritis care & research, 2020
Health disparities in patient‐reported outcomes by income and education are well documented; however, the impact of health literacy on patient‐reported outcomes has received less attention. We examined independent effects of income, education, and health
P. Katz, M. Dall'era, L. Trupin, Stephanie Rush, L. Murphy, C. Lanata, L. Criswell, J. Yazdany   +7 more
semanticscholar   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Systematic review of the use of translated patient-reported outcome measures in cancer trials

Trials, 2021
Background Patient-reported outcomes (PROs) are used in clinical trials to assess the effectiveness and tolerability of interventions. Inclusion of participants from different ethnic backgrounds is essential for generalisability of cancer trial results ...
A. L. Slade, A. Retzer, K. Ahmed, D. Kyte, T. Keeley, J. Armes, J. M. Brown, L. Calman, A. Gavin, A. W. Glaser, D. M. Greenfield, A. Lanceley, R. M. Taylor, G. Velikova, G. Turner, M. J. Calvert   +15 more
doaj   +1 more source

Comorbidities in Patients with Rheumatoid Arthritis and Their Association with Patient-reported Outcomes: Results of Claims Data Linked to Questionnaire Survey

Journal of Rheumatology, 2019
Objective. To investigate the prevalence of comorbidities in a population-based cohort of persons with rheumatoid arthritis (RA) compared to matched controls and to examine their association with patient-reported outcomes in a survey sample.
A. Luque Ramos, I. Redeker, F. Hoffmann, J. Callhoff, A. Zink, K. Albrecht   +5 more
semanticscholar   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

The Japanese version of the National Cancer Institute’s patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE): psychometric validation and discordance between clinician and patient assessments of adverse events

Journal of Patient-Reported Outcomes, 2018
BackgroundThe Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) was developed by the National Cancer Institute as an adverse event assessment system to evaluate patients’ symptoms, which tend to be ...
T. Kawaguchi, Kanako Azuma, M. Sano, Soan Kim, Yosuke Kawahara, Yoko Sano, Tomohide Shimodaira, K. Ishibashi, T. Miyaji, E. Basch, Takuhiro Yamaguchi   +10 more
semanticscholar   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Patient-Reported Outcomes: Conceptual Issues

Value in Health, 2007
There is a broad agreement that patient-reported outcome (PRO) assessment in health care should proceed from a strong conceptual basis, with rationales clearly articulated in advance concerning what is to be measured and how this is to be accomplished.
Philippe Beltran, Joseph Lipscomb, Joseph C. Cappelleri, Bonnie Teschendorf, Margaret Rothman   +4 more
openaire   +2 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Perfect health not so perfect after all – a methodological study on patient-reported outcome measures in 2574 patients following percutaneous coronary intervention

Health and Quality of Life Outcomes
Background Patient-reported outcome measures (PROMs) are crucial to capture patients’ health and illness status. Selecting the most suitable PROM to measure self-reported health in a specific study population is essential.
T. M. Norekvål, M. M. Iversen, K. Oterhals, H. Allore, B. Borregaard, T. R. Pettersen, D. R. Thompson, A. D. Zwisler, K. Breivik   +8 more
doaj   +1 more source