Results 61 to 70 of about 51,447 (275)

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

A systematic study of independently-tuned room-specific PBS beam model in a beam-matched multiroom proton therapy system

Radiation Oncology, 2021
Background In the existing application of beam-matched multiroom proton therapy system, the model based on the commissioning data from the leading treatment room was used as the shared model.
Yu-Hua Huang, Chunfeng Fang, Tao Yang, Lin Cao, Gaolong Zhang, Baolin Qu, Yihang Zhang, Zishen Wang, Shouping Xu   +8 more
doaj   +1 more source

Emotions and scope effects in the monetary valuation of health [PDF]

, 2018
JEL classifications: H41 H51 I11 I18 I31This study presents evidence on the role of emotions in the monetary evaluation of health technologies, namely, drug-eluting stents (DES) in our case.
Araña, Jorge, Avilés Blanco, Maria V., Brey, Raúl, Pinto Prades, Jose Luis   +3 more
core   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Characterization of 3D printing techniques: Toward patient specific quality assurance spine-shaped phantom for stereotactic body radiation therapy. [PDF]

PLoS ONE, 2017
Development and comparison of spine-shaped phantoms generated by two different 3D-printing technologies, digital light processing (DLP) and Polyjet has been purposed to utilize in patient-specific quality assurance (QA) of stereotactic body radiation ...
Min-Joo Kim, Seu-Ran Lee, Min-Young Lee, Jason W Sohn, Hyong Geon Yun, Joon Yong Choi, Sang Won Jeon, Tae Suk Suh   +7 more
doaj   +1 more source

Reduction of systematic dosimetric uncertainties in volumetric modulated arc therapy triggered by patient-specific quality assurance

Physics and Imaging in Radiation Oncology, 2022
Background and purpose: Dosimetric patient-Specific Quality Assurance (PSQA) data contain in addition to cases with alerts, many cases without alerts.
Anton Mans, Roel Rozendaal, Tomas Janssen, Eugène Damen, Jochem Kaas, Anke van Mourik, Ben Mijnheer   +6 more
doaj   +1 more source

MedTruth: A Semi-supervised Approach to Discovering Knowledge Condition Information from Multi-Source Medical Data

, 2019
Knowledge Graph (KG) contains entities and the relations between entities. Due to its representation ability, KG has been successfully applied to support many medical/healthcare tasks.
Deng, Yang, Du, Nan, Fan, Wei, Lei, Kai, Li, Yaliang, Shen, Ying, Yang, Min   +6 more
core   +1 more source

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

Advanced Science, EarlyView.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos, Gustavo Felizardo Santos Sandes, Artur Christian Garcia da Silva, Holli‐Joi Martin, Eugene N. Muratov, Rodolpho de Campos Braga, Bruno Junior Neves   +6 more
wiley   +1 more source

Dosimetric Validation of Treatment Plan Interchangeability between Factory Beam-matched Varian TrueBeam and Clinac Linear Accelerators for Volumetric Modulated Arc Therapy and IMRT Delivery

Journal of Medical Physics
Purpose: The purpose of this study was to assess the dosimetric consistency and clinical interchangeability of treatment plans between factory beam-matched Varian TrueBeam SVC and Clinac iX linear accelerators across various anatomical locations ...
Mukesh Kumar Zope, Deepali Patil, Seema Devi, Devraj Singh   +3 more
doaj   +1 more source

Professional practice changes in radiotherapy physics during the COVID-19 pandemic

Physics and Imaging in Radiation Oncology, 2021
Background and purpose: The COVID-19 pandemic has imposed changes in radiotherapy (RT) departments worldwide. Medical physicists (MPs) are key healthcare professionals in maintaining safe and effective RT.
Jenny Bertholet, Marianne C. Aznar, Cristina Garibaldi, David Thwaites, Eduard Gershkevitsh, Daniela Thorwarth, Dirk Verellen, Ben Heijmen, Coen Hurkmans, Ludvig Muren, Kathrine Røe Redalen, Frank-André Siebert, Marco Schwarz, Wouter Van Elmpt, Dietmar Georg, Nuria Jornet, Catharine H. Clark   +16 more
doaj   +1 more source