Results 171 to 180 of about 31,391,825 (411)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Enhancing Transparency in Optimum Patient Care Research Database Access Procedures: A Multifaceted Approach Addressing Improvements in Transparency Standards

International Journal of Population Data Science
Background In healthcare research, leveraging data is vital for driving advancements in treatment, diagnosis, and healthcare delivery. However, transparency in data use is pivotal for credible, reproducible findings.
Emma-Jane Loveridge, Adam Marsh, Francis Appiagyei, Chris Price, David Price, Victoria Carter   +5 more
doaj   +1 more source

Diagnostic value of troponin T for alterations in left ventricular mass and function in dialysis patients [PDF]

, 2002
Francesca Mallamaci, Carmine Zoccali, Saverio Parlongo, Giovanni Tripepi, Francesco Benedetto, Sebastiano Cutrupi, Grazia Bonanno, Pasquale Fatuzzo, Francesco Rapisarda, Giuseppe Seminara, Benedetta Stancanelli, Ignazio Bellanuova, Alessandro Cataliotti, Lorenzo Malatino   +13 more
openalex   +1 more source

Shared Care Contributions to Self-Care and Quality of Life in Chronic Cardiac Patients [PDF]

, 2016
Shared care is an interpersonal interaction system composed of communication, decision making, and reciprocity; it is used by patients and family caregivers (care dyads) to exchange social support.
Brown, Roger, Flatley Brennan, Patricia, Sebern, Margaret   +2 more
core   +1 more source

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

Science, 2018
G. Vlachogiannis, S. Hedayat, A. Vatsiou, Y. Jamin, J. Fernández-Mateos, K. Khan, A. Lampis, Katherine Eason, Ian Huntingford, R. Burke, M. Rata, D. Koh, N. Tunariu, D. Collins, Sanna Hulkki-Wilson, C. Ragulan, I. Spiteri, S. Moorcraft, I. Chau, S. Rao, D. Watkins, N. Fotiadis, M. Bali, M. Darvish-Damavandi, H. Lote, Z. Eltahir, E. Smyth, R. Begum, P. Clarke, J. Hahne, M. Dowsett, J. D. de Bono, P. Workman, A. Sadanandam, M. Fassan, O. Sansom, S. Eccles, N. Starling, C. Braconi, A. Sottoriva, S. Robinson, D. Cunningham, N. Valeri   +42 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Patient Safety Alert: Serious Harm Associated With Failure to Adjust Clozapine Dosing

Patient Safety, 2023
Patient Safety Authority
doaj   +1 more source

Lung Health and Respiratory Syncytial Virus: Podcast of a Patient–Physician Discussion Based on Insights from a Patient Advisory Board Meeting

Infectious Diseases and Therapy
An advisory board meeting was held with five participants living with chronic respiratory conditions or having experienced a severe episode of respiratory syncytial virus (RSV) infection, to understand the challenges faced by such individuals and their ...
Bela Vatsa, Lisa McNeil, Peter Deussen, Steven Homewood, Steven Worsnip, Frithjof Kosfeld   +5 more
doaj   +1 more source