Results 171 to 180 of about 8,891,374 (288)

Association Between Patient Behavior and Clinician Emotional Burden, Perceived Performance, and Decision-Making in Implant Dentistry: A Cross-Sectional Study Among Clinicians. [PDF]

Clin Exp Dent Res
Pachiou A, Humm VL, Naenni N, Kontonasaki E, Jung RE, Thoma DS.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Involving Patients in Pharmacoepidemiology Studies Conducted on Healthcare Administrative Database: Results of a Feasibility Study in France. [PDF]

Health Expect
Rigoureau J, Verroul M, Vieillard V, Termoz A, Panse L, Havet A, Viprey M, Haesebaert J.   +7 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Acceptability of a Pilot Digital Longitudinal Consultation Clinical Placement for Early-Year Medical Students, Tutors and Patients. [PDF]

Clin Teach
Huang T, Laidlaw A, Falconer R, Patey R.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Mind the Gap: A Qualitative Study of Patients' Experiences of Acute Elective Care Across the NHS and the Private Sector in England. [PDF]

Health Expect
Gee E, Stringer G, Ferguson J, Molete M, Walshe K, Grigoroglou C, Allen T, Anderson M, Gutacker N, Bloor K.   +9 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Assessing the Impact of an Undergraduate Medical Student Volunteer Hospital Program: Active Mind Active Body. [PDF]

Clin Teach
Nanda K, Rasmuson J, Lau JT, Mathura P, Sia WW.   +4 more
europepmc   +1 more source

Addendum to “Patient Safety Alert: Serious Harm Associated With Failure to Adjust Clozapine Dosing”

Patient Safety
Patient Safety Authority
doaj   +1 more source