Results 211 to 220 of about 7,913,772 (288)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Between Conjugal Duty and Sexual Freedom: The European Court of Human Rights Breaks the Taboo in HW v France

European Constitutional Law Review
Patient Mpunga-Biayi
doaj   +1 more source

Anesthetic Management in a Patient With Tethered Spinal Cord Syndrome Undergoing Knee Replacement Surgery. [PDF]

Case Rep Anesthesiol
Alessi L, Bonham A, Wendell K, Eisenhauer J, Bolbolan S, Reshetnikoff E, Alessi R, McEchron M.   +7 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Association of nurse staffing ratios with patient mortality and length of stay in Chilean public hospitals: a cross-sectional study. [PDF]

BMJ Open
Simonetti M, Galiano A, Agüero A, Lasater KB, Lake ET, Aiken LH.   +5 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Clinician- and facility-level factors associated with chemotherapy dose reductions in stages I-IIIA breast cancer. [PDF]

J Natl Cancer Inst
Sampathkumar Y, Zakaria Z, O'Connell K, Bhimani J, Blinder VS, Burganowski R, Ergas IJ, Gallagher GB, Griggs JJ, Heon N, Kolevska T, Kotsurovskyy Y, Kroenke CH, Laurent CA, Liu R, Monroy-Iglesias MJ, Nakata KG, Persaud S, Roh JM, Tabatabai S, Valice E, Wang P, Bandera EV, Aiello Bowles EJ, Kushi LH, Kantor ED.   +25 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Exploring patient motivations and preferences for medical data sharing with researchers: a simulation study using the iAgree platform. [PDF]

J Am Med Inform Assoc
Keller MS, Nguyen AT, Leder C, Chen Y, Morse B, Schilling LM, Hu D, SooHoo S, Ohno-Machado L.   +8 more
europepmc   +1 more source