Results 111 to 120 of about 5,399,581 (311)

Activities of Life: The COPD Patient

COPD: Journal of Chronic Obstructive Pulmonary Disease, 2009
Chronic obstructive pulmonary disease (COPD) is a chronic, progressive and debilitating disease. With worsening disease, a COPD patient will progressively become less physically active, will have reduced social contacts, and this will create a downward vicious circle.
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Longitudinal trajectories and influencing factors of activation in chronic heart failure patients based on latent class growth model

Huli yanjiu
ObjectiveTo explore the potential categories of longitudinal trajectories of patient activation in individuals with chronic heart failure and to analyze their influencing factors.MethodsPatients with chronic heart failure admitted to our hospital from ...
CHEN Min, YUAN Xian, GENG Juan
doaj  

Awareness, want, and adoption of digital health services among older adults in China: a cross-sectional study

Frontiers in Public Health
BackgroundPopulation ageing is increasing the demand for chronic disease management, long-term care, and continuous health services, and has become a major public health challenge. This issue is particularly salient in China, where by 2020 adults aged 60 
Sitong Wu, Zheng Wan, Lihui Peng, Qifan Zhang, Xiaoyi Wu, Xiaoying Lin, Xiaoying Lin   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Patient safety in health care professional educational curricula: examining the learning experience [PDF]

, 2009
This study has investigated the formal and informal ways pre-registration students from four healthcare professions learn about patient safety in order to become safe practitioners.
Steven, Alison, Pearson, Pauline, Dawson, Pam   +2 more
core  

Does Patient Experience Change with Age? Exploring Associations Between Patient Experience, Gender and Age [PDF]

Patient experience measurement is important for healthcare organizations to support the provision of high-quality care. Although previous research suggests age and gender may influence patient experiences, a thorough analysis of these associations ...
Adams, Corey, Sharma, Anurag, Walsan, Ramya, Walpola, Ramesh, Schembri, Anthony, Harrison, Reema   +5 more
core   +1 more source

Importance of patient online activities

The British Journal of Psychiatry
Online platforms and activities, including smartphones, computers, social media, video games and applications involving artificial intelligence, have become a regular part of daily life and offer individuals a wide range of benefits. The purpose of this document is to increase psychiatrists’ awareness of the frequency and potential risks associated ...
Scott Monteith, Tasha Glenn, John R. Geddes, Peter C. Whybrow, Eric Achtyes, Rita Bauer, Michael Bauer   +6 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source