Results 171 to 180 of about 224,959 (261)

A case study of patient and public involvement in sepsis genomics research. [PDF]

Res Involv Engagem
Lee A, Qin H, Cano-Gamez K, Knight JC.
europepmc   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

Digital health interventions for patient engagement: A systematic umbrella review. [PDF]

PLOS Digit Health
Iqbal U, Nkhoma DE, Manga YB, Tanweer A, Bokhari SMH, Wibowo MF, Ningrum DNA, Rahmanti AR, Huang CW, Yang HC, Atique S, Moldovan M, Humayun A, Lazuardi L, Rajaguru G, Mickan S, Celi LA, Li YJ, Redfern J.   +18 more
europepmc   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Understanding factors affecting patient and public engagement and recruitment to digital health interventions: a systematic review of qualitative studies. [PDF]

BMC Med Inform Decis Mak, 2016
O'Connor S, Hanlon P, O'Donnell CA, Garcia S, Glanville J, Mair FS.   +5 more
europepmc   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Towards meaningful engagement: theoretical approaches guiding the participation of people living with multiple long-term conditions in health research - a scoping review. [PDF]

BMJ Public Health
Chopra M, Rajkhowa P, Ghosal S, Ikhile D, Rao N, Gupta M, Cassambai S, Srinivasapura Venkateshmurthy N, Oli N, Pachya AT, Highton P, Waring J, Mohan S, Vaidya A, Singh K, Khunti K, Prabhakaran D, Arora M.   +17 more
europepmc   +1 more source

Barriers and facilitators to patient and public engagement and recruitment to digital health interventions: protocol of a systematic review of qualitative studies. [PDF]

BMJ Open, 2016
O'Connor S, Hanlon P, O'Donnell CA, Garcia S, Glanville J, Mair FS.   +5 more
europepmc   +1 more source