Results 201 to 210 of about 224,959 (261)

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Building the bridge as you cross it - a process evaluation of the implementation of a clinically integrated living lab in Swedish public primary care. [PDF]

Scand J Prim Health Care
Samuelson S, Petersson EL, Hange D, Björkelund C, Persson Kylén S, Östman M, Svenningsson I.   +6 more
europepmc   +1 more source

Indicator Development for the Evaluation of User-Researcher Collaboration in Health Research: A Co-Designed, Modified Delphi-Study. [PDF]

Health Expect
Verweij L, Safford J, Oesch S, Kohler M, Zurbrügg T, Brülhart T, Jourdan M, Marinello CB, Naef R.   +8 more
europepmc   +1 more source

Patient and Public Involvement and Engagement (PPIE) in methodological research: exploring challenges, tensions and learning from the perspectives of PPIE and researchers in the Realist Economic Evaluation Methods (REEM) study. [PDF]

Res Involv Engagem
Fletcher A, Rook V, Mountain S, Shenton F, Fenocchi L, Kumar MB, Dalkin S, Bate A, Hunter R.   +8 more
europepmc   +1 more source

Engagement and Retention in Precision Public Health: A Cascade Analysis of Two Cluster Randomized Trials.

Public Health Genomics
Macon J, Lateef A, Aton A, Smock N, Salyer P, Rammaha T, Politi MC, Bierut LJ, Chen LS, Ramsey AT.   +9 more
europepmc   +1 more source

Patient and public engagement in UK medical education

, 2017
openaire   +1 more source