Results 211 to 220 of about 99,154 (254)

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Determining a role for Patient and Public Involvement and Engagement (PPIE) in genomic data governance for cancer care. [PDF]

Eur J Hum Genet
Sahan K, Turner L, Hallowell N, Parker M, Lucassen A.   +4 more
europepmc   +1 more source

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

A Bibliometric Analysis of Healthcare Intervention-Related Studies Reporting Patient and Public Involvement and Engagement. [PDF]

Healthcare (Basel)
Lu W, Li Y, Montayre J, Li M, Ho KY, Li J, Yorke J.   +6 more
europepmc   +1 more source

Data, dialogue, and design: patient and public involvement and engagement for natural language processing with real-world cancer data. [PDF]

Front Digit Health
Oyewusi W, Vasquez Osorio EM, Nenadic G, MacGregor I, Price G.   +4 more
europepmc   +1 more source

Five years of patient and public involvement and engagement (PPIE) in the development and evaluation of the Pain-at-Work toolkit to support employees' self-management of chronic pain at work. [PDF]

Res Involv Engagem
Blake H, Abbott-Fleming V, Greaves S, Somerset S, Chaplin WJ, Wainwright E, Walker-Bone K.   +6 more
europepmc   +1 more source

Value and Implementation of Patient and Public Involvement and Engagement in Health Technology Assessment for Japan: implications from systematic searches. [PDF]

Int J Technol Assess Health Care
Kaneyasu T.
europepmc   +1 more source

Exploring the purpose and stages of patient and public involvement and engagement (PPIE) in audiology research: a case study approach. [PDF]

Res Involv Engagem
Pryce H, Dhanda N, Straus J.
europepmc   +1 more source