Results 121 to 130 of about 620,040 (295)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mit PROM und PREM zu Patient Centered Care

Monitor Versorgungsforschung
In Deutschland ist der aktuelle Stand der Nutzung von Patient-Reported Outcome Measures (PROM) und Patient-Reported Experience Measures (PREM) ausbaufähig. Derzeit erfolgt hierzulande die Anwendung dieser Instrumente eher noch in einem fragmentierten und
Peter Stegmaier
doaj   +1 more source

Psychometric Evaluation and Design of Patient-Centered Communication Measures for Cancer Care Settings [PDF]

, 2017
Objective To evaluate the psychometric properties of questions that assess patient perceptions of patient-provider communication and design measures of patient-centered communication (PCC). Methods Participants (adults with colon or rectal cancer living
Bann, Carla M., He, Jason, Jackson, Kathryn D., Mack, Nicole, Magnus, Brooke E., Mann, Courtney, McCormack, Lauren A., Moultrie, Rebecca, Reeve, Bryce B., Roach, Nancy, Sanoff, Hanna K., Thissen, David M., Treiman, Katherine, Wagner, Laura K.   +13 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Teaching Culturally Sensitive Care to Dental Students: A Multidisciplinary Approach [PDF]

, 2014
Dental schools must prepare future dentists to deliver culturally sensitive care to diverse patient populations, but there is little agreement on how best to teach these skills to students.
Donate-Bartfield, Evelyn, Lobb, William K., Roucka, Toni M.   +2 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Six ways to get a grip on patient and family centered care during the undergraduate medical years

Canadian Medical Education Journal
Patient and family-centered care and patient engagement practices have strong evidence-based links with quality and safety for both patients and health care providers.
Krista Baerg, Tara Anderson, Heather Thiessen   +2 more
doaj   +1 more source

Patient/Family Education for Newly Diagnosed Pediatric Oncology Patients [PDF]

, 2016
There is a paucity of data to support evidence-based practices in the provision of patient/family education in the context of a new childhood cancer diagnosis.
Ahern, JoAnn, Barakat, Lamia P., Bhatia, Smita, Bingen, Kristin M., Bondurant, Patricia G., Cohn, Susan L., Dobrozsi, Sarah K., Haugen, Maureen, Herring, Ruth Anne, Hockenberry, Marilyn, Hooke, Mary C., Landier, Wendy, Martin, Melissa, Murphy, Kathryn, Newman, Amy R., Rodgers, Cheryl C., Ruccione, Kathleen S., Sullivan, Jeneane, Weiss, Marianne E., Withycombe, Janice, Yasui, Lise   +20 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source