Results 101 to 110 of about 5,028,715 (249)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

The Comparison of Preemptive Oral Tramadol, Gabapentin Tramadol and Parasetamol Tramadol Combination on the Efficacy of Postoperative Pain Control in Breast Reduction Surgery

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2013
Purpose: Application of tramadol by intravenous patient controlled analgesia (PCA) is a routine method for controlling postoperative pain in the breast reduction operations.
Muge Can, Zehra Hatipoglu, Cengiz Eser, Yasemin Gunes   +3 more
doaj  

Postoperative Patient-controlled Analgesia: Thirty Years of Clinical Experience in Peking Union Medical College Hospital

Xiehe Yixue Zazhi
Postoperative pain seriously affects the recovery process of patients, resulting in prolonged hospital stay and increased care costs. Appropriate application of patient-controlled analgesia devices can effectively relieve perioperative acute pain.
ZHAO Lin, REN Liying, NIE Weihua, CHEN Yaqi, ZHANG Jie, ZHANG Shengjie, WANG Yingli, DIAO Cuicui, MA Huiying, ZHANG Zheng, ZHOU Li, SHEN Le, WANG Huizhen, HUANG Yuguang   +13 more
doaj   +1 more source

Patient-controlled analgesia for burn patients: a preliminary report

, 1988
The introduction of patient-controlled analgesia for burn patients is reported. It has been used for 18 postoperative patients and five patients with acute thermal injury. The system has been found to be easy to use.
Glavin, R., Kinsella, J., Reid, W.H.
core   +4 more sources

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2‐mediated α7nAChR/NF‐κB pathway

Animal Models and Experimental Medicine, EarlyView.
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Mengwei Dong, Wenfang Li, Wanpeng Yang, Te Ba, Nan Nan, Yang Liu, Jing Han, Huiqin Hao   +7 more
wiley   +1 more source

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

The Effects of Tramadol and Levobupivacaine Infiltration on Postoperative Analgesia in Functional Endoscopic Sinus Surgery and Septorhinoplasty

Balkan Medical Journal, 2012
Objective: The aim of this prospective, randomized, double-blind study was to investigate the postoperative analgesic effects of levobupivacaine or tramadol infiltration administered prior to surgery in septorhinoplasty (SRP) or endoscopic sinus surgery (
Gökşen Öz, Alparslan Apan, Muhammet Hilmi Koputan, Emine Arzu Köse   +3 more
doaj  

Patient-controlled sedation and analgesia during SWL

, 1996
13th World Congress on Endourology and SWL -- NOV, 1995 -- JERUSALEM, ISRAELSixty unpremedicated outpatients undergoing elective extracorporeal shockwave lithotripsy (SWL) using a Dornier MPL 9000 lithotripter were randomly assigned to receive either ...
Uyar, M, Ozyurt, C, Ozyar, B, Bilge, S, Ugur, G   +4 more
core   +1 more source

Refining OVCAR‐3 xenograft models of peritoneal carcinomatosis in nu/nu mice: Comparative intraperitoneal implantation strategies and the role of basement membrane matrix

Animal Models and Experimental Medicine, EarlyView.
A refined murine model of advanced ovarian cancer was established by comparing localized preperitoneal implantation and intraperitoneal injection of OVCAR‐3Luc cells. While localized implantation showed limited tumor persistence, intraperitoneal delivery with BME produced sustained diffuse dissemination confirmed by BLI and histology, providing a ...
M. Teresa Perelló‐Trias, Antonio Jose Serrano‐Muñoz, Juan J. Segura‐Sampedro, Adriana M. Quintero‐Duarte, Joana M. Ramis, Marta Monjo   +5 more
wiley   +1 more source

Using patient-controlled analgesia multimedia intervention for improving analgesia quality

, 2016
[[abstract]]AIM: To evaluate the effects of analgesia quality provided by a patient-controlled analgesia multimedia intervention on the pain management of postsurgical patients in Taiwan.
Yeh, Mei-Ling;Yang, Hui-Ju;Chen, Hsing-Hsia;Tsou, Mei-Yung, 葉美玲   +1 more
core