Results 111 to 120 of about 2,660,078 (356)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Are We Practicing What We Are Taught in Health Professions’ Education? Coproducing Health Care [PDF]

open access: yes, 2018
Health-care providers and educators are inherently empathetic, compassionate, experienced professionals who entered their profession to assure the complementary missions of public health and health care.
Caron, Rosemary M.   +1 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Incorporating patient and public involvement (PPI) at the design stage of an early career physiotherapy researcher's funding application: A co-produced reflective case report

open access: yesSocial Sciences and Humanities Open
Aim: Patient and public involvement (PPI) in health and social care research is a requirement of nationally peer reviewed funders and the National Institute for Health Research (NIHR), including research grant applications.
Jacqueline Bennion   +5 more
doaj   +1 more source

Readability of Online Patient Education Materials in Radiation Oncology – Are We Improving? [PDF]

open access: bronze, 2019
Michael K. Rooney   +4 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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