Results 121 to 130 of about 1,375,311 (317)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Symptom Management Through Patient Education
Nursing Praxis in Aotearoa New Zealand, 1989 Cancer - the very word is a huge burden to any patient who hears that diagnosis applied to themselves. The word describes a disease process which may arise in any organ of the body and which may produce a variety of problems or symptoms.
Dora Mak
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Social Sciences and Humanities OpenAim: Patient and public involvement (PPI) in health and social care research is a requirement of nationally peer reviewed funders and the National Institute for Health Research (NIHR), including research grant applications.
Jacqueline Bennion +5 more
doaj +1 more source
How patient-centred am I? : A new method to measure physicians' patient-centredness
, 2006 ObjectiveTo describe a new method to determine physicians’ self-perceived degree of patient-centredness. A pilot study combining qualitative and quantitative methods.MethodsForty-one general practitioners (GPs) answered a questionnaire consisting of ...
Rosenqvist, Urban, +2 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Meaningful and effective patient engagement: What matters most to stakeholders
, 2015 To determine what resources, preparation, and support are needed for patients, providers, and leaders to meaningfully and appropriately engage in patient-centred health system redesign, researchers sought to learn what really matters to these three ...
Bellows, Mandy +9 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Pat›ent Educat›on Act›v›t›es Of Nurses and Patient Education Process
Florence Nightingale Journal of Nursing, 2019 The variations and developments in health-care system obligate nurses to base on contemporary knowledge and practice in their fuctions and appropriate life-long education and have importance their health/patient education role in activities related to ...
Emine Şenyuva, Gülsün Taşocak
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