Results 71 to 80 of about 2,660,078 (356)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Survey of Nurses' and Patients' Opinions about Patient Education and Training and Possible Barriers in Madani Cardiovascular Health and Education Center [PDF]

Taṣvīr-i salāmat, 2017
Background and Objectives: Patient education is an effective nursing care to increase patient satisfaction with health care, reduce anxiety and the length of hospitalization and costs.
Afkham Varghaei-Paidar, Vahideh Zareh Gavgani, Nader Hassannejhad, Saeedeh Ranjbar, Marzieh Hosseinzadeh, Shahin Imani   +5 more
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Examination of Acute Care Nurses Ability to Engage in Patient Education Related to Physical Activity as a Health Behavior [PDF]

, 2012
Physical activity is important for management and prevention of chronic disease. The current physical activity guidelines recommend engaging in physical activity for at least 30 minutes per day on at least 5 days a week.
Bayles, Constance, Hoffman, Leslie, Jakicic, John, Miketic, Joyce, Zewe, Gretchen/E   +4 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

From observation to action: a qualitative interview study of factors that influence the reporting of observations of unprofessional conduct in healthcare settings

BMJ Open Quality
Background Unprofessional behaviour in healthcare settings can undermine patient safety, erode team morale, and if not addressed, negatively impact organisational culture.
William Martinez, Gerald B Hickson, William O Cooper, Lynn E Webb, Michelle Troyer, Nicolette M Kostiw   +5 more
doaj   +1 more source

Ethnicity recording in health and social care data collections in Ireland: where and how is it measured and what is it used for?

International Journal for Equity in Health, 2019
Background In the European Union (EU), discrimination based on racial and ethnic origin is prohibited under the Racial Equality Directive. Ireland is one of only three EU countries where a legal duty of equality data collection is placed on public bodies.
Ailish Hannigan, Nazmy Villarroel, Maria Roura, Joseph LeMaster, Alphonse Basogomba, Colette Bradley, Anne MacFarlane   +6 more
doaj   +1 more source

Readability and understandability of andrology questionnaires [PDF]

, 2018
Objective: Medical questionnaires, which enable collection, comparison and analysis of appropriate data as a means of written communication between a patient and a doctor, must be easily readable, and understandable. Here, we measure the readability and
Atalay, Hasan Anıl, Çetinkaya, Gökhan
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

User perceptions of intelligent offloading diabetic footwear

Frontiers in Endocrinology
AimsAdherence to therapeutic footwear is vital for effective diabetic foot ulcer prevention and treatment. Understanding the key adherence factors and potential barriers is important for footwear design and implementation.
Sarah L. Hemler, Sarah L. Hemler, Carolyn M. Sommerich, Jorge C. Correia, Jorge C. Correia, Zoltan Pataky, Zoltan Pataky, Zoltan Pataky   +7 more
doaj   +1 more source