Results 81 to 90 of about 120,447,991 (312)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

How patient-centered is education and counseling of patients treated with oral anticancer drugs? A multicenter cross-sectional study

, 2023
Objective: In this multicenter cross-sectional study, the quality of patient-centered education and counseling for patients treated with oral anticancer drugs was examined.Methods: The CONTACT-Patient-Centered Care Questionnaire was administered to 266 ...
Van Hecke, AnnGE39UZGent0019943162598010018234550000-0003-3576-7159F702A1AC-F0ED-11E1-A9DE-61C894A0A6B4, Foulon, Veerle, Kinnaer, Lise-MarieGE398020036259170000-0003-3666-81288d40c178-4897-11eb-bce0-d97a09885304, Kenis, Ilyse0001914907308020029879399751419364520000-0002-6049-145XAEE5751E-C5C8-11E8-8987-A2685607D3EF   +3 more
core  

Emergency physicians perspectives of state continuing medical education requirements for medical licensure

Journal of the American College of Emergency Physicians Open
Objectives This study aims to better understand the perspectives of emergency medicine physicians’ on the role that state‐mandated, topic‐specific continuing medical education (CME) plays in addressing knowledge gaps, its relevance to current emergency ...
Marianne Gausche‐Hill, Yachana Bhakta, Michael C. Bond, Sandra M. Schneider, Jeffrey Druck, Colleen E. Livingston, Lisa Moreno‐Walton, Jonathan S. Jones, Melissa A. Barton   +8 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The topic-prominence parameter [PDF]

, 2013
This article aims to recast the properties of topic-prominent languages and their differences from subject-prominent languages as documented in the functionalist literature into the framework of the Principle-and-Parameter approach.
Xu, Liejiong
core  

CRITICAL APPRAISAL TOPIC ON PATIENT EDUCATION ON ADVANCE DIRECTIVES IN END-OF-LIFE CARE

KnE Life Sciences, 2018
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openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The Weber health education model : health care provider-patient interactions [PDF]

, 2004
ix, 128 leaves ; 29 cm. --This qualitative project introduces and explores the creation of a new health education model, which emerged from a personal narrative inquiry. Using research literature and studying four patient interactions through narrative
University of Lethbridge. Faculty of Education, Weber, Lorelei Diane   +1 more
core  

The Effect of Collaborative Patient Simulation in Health Education Students: A Critically Appraised Topic

CommonHealth
Context: Patient simulations are one pedagogical strategy that educators use to prepare students for interprofessional practice. Students must work in multidisciplinary teams to enhance patient care. Objective: What is the efficacy of collaborative patient simulation for increasing Students’ Perceptions of Interprofessional Clinical Education-Revised ...
Jamie Mansell, Anne Russ, Ryan Tierney, Amber Melick   +3 more
openaire   +1 more source

Ethical, professional, and legal obligations in clinical practice: a series of discussion topics for postgraduate medical education Topic 3: resuscitation decisions in adult patients [PDF]

Postgraduate Medical Journal, 2001
This is the third discussion topic in a series of five dealing with ethical, professional, and legal obligations of clinical practice. Junior doctors tend to lack confidence in these subjects, and thus I organised a series of informal discussions in our surgical unit on which these articles are based.
openaire   +2 more sources