Results 71 to 80 of about 259,031 (315)

Ethical Issues in Patients with Leukemia: Practice Points and Educational Topics for the Clinical Oncologist and Trainees

Journal of Clinical Research & Bioethics, 2017
Leukemia represents a complex spectrum of malignancies, involving numerous treatment options and substantial symptom burden for patients. Ethical dilemmas may arise which challenge a physician's clinical management and the patient's goals of care. What is needed is the systematic analysis of the most common issues that confront clinical teams treating ...
Jeffery S Farroni, Phillp A Thompson, Daud Arif, Jorge E Cortes, Colleen M Gallagher   +4 more
openaire   +1 more source

Evaluation of a Patient Education Game Design Activity

, 2023
Background: Game-based learning has been used in pharmacy education settings with the instructor developing a game for students to play to enhance learning. However, there is a paucity of data about health sciences students designing a game themselves to
Andrea Porter, Olufunmilola Abraham, Olivia Kim   +2 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

PARQVE: PROJECT ARTHRITIS RECOVERING QUALITY OF LIFE THROUGH EDUCATION: TWO-YEAR RESULTS [PDF]

Acta Ortopédica Brasileira, 2017
Objective: To evaluate the effects of a multi-professional educational program in patients with knee osteoarthritis (KOA) . Methods: Prospective randomized controlled trial with 195 KOA patients.
MÁRCIA UCHOA DE REZENDE, RENATO FRUCCHI, ALEXANDRE FELÍCIO PAILO, GUSTAVO CONSTANTINO DE CAMPOS, THIAGO PASQUALIN, MARCELO ISSAO HISSADOMI   +5 more
doaj   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effectiveness of musculoskeletal education interventions in people with low literacy levels: a systematic review. [PDF]

, 2013
OBJECTIVE: To conduct a systematic review to assess the effectiveness of patient education interventions delivered or directed by health professionals for people with musculoskeletal conditions who also have lower levels of literacy.
Protheroe
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

People with young-onset dementia and their family caregivers discussing euthanasia : a qualitative analysis of their considerations

, 2023
Objectives: Research showed that people with young-onset dementia and their family caregivers raised the topic of euthanasia when talking about the broader topic of advance care planning.
Chambaere, KennethGE390020001958738020009676120000-0001-6277-072X32676AE8-F0EE-11E1-A9DE-61C894A0A6B4, Van den Block, LieveUGent801001703419977708578579325757A2-F0EE-11E1-A9DE-61C894A0A6B4, Van Rickstal, Romy, De Vleminck, AlineGE3900008053495580200098590113EC4A02-F0EE-11E1-A9DE-61C894A0A6B4   +3 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Exploration and Practice of an Innovative Model of Community-based Popularization of Knowledge in Critical Care Medicine [PDF]

Zhongguo quanke yixue
Popularization of medical knowledge plays an important role in promoting effective communication and understanding between doctors and patients.
ZOU Hai, CHEN Zhenyao, HE Xigan, MOU Xiaozhou, ZHANG Zhongwei, ZHU Biao, WEI Peng, LIU Jing
doaj   +1 more source