Results 101 to 110 of about 8,661,270 (305)

Living With Hypochondroplasia: A Qualitative Exploration of Children's and Caregivers' Experiences, Challenges, and Unmet Needs

Molecular Genetics & Genomic Medicine
Background Hypochondroplasia (HCH) is a rare genetic skeletal dysplasia characterized by short stature, disproportionate limbs, and complications such as learning differences.
Elisabeth M. Oehrlein, Reni Pekala, Stacie Cavallaro, Margaret Cho, Chandler Crews, Andrew Dauber, Ankita Saxena, Joe Vandigo, Emily S. Reese   +8 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Patient-reported outcome measures for primary hyperparathyroidism: a systematic review of measurement properties

Health and Quality of Life Outcomes
Background The quality of patient-reported outcome measures (PROMs) used to assess the outcomes of primary hyperparathyroidism (PHPT), a common endocrine disorder that can negatively affect patients’ health-related quality of life due to chronic symptoms,
George Liang, Manraj N. Kaur, Carrie G. Wade, Maria O. Edelen, David W. Bates, Andrea L. Pusic, Jason B. Liu   +6 more
doaj   +1 more source

Reframing the conversation on patient experience: Three considerations [PDF]

, 2019
In experience, every voice matters, and each of those individual voices are contributing to an ocean of ripples that are positively impacting countless lives.
Wolf, Jason A, PhD, CPXP
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The patient experience movement moment [PDF]

, 2014
For years, the patient experience movement has continued to gain momentum. From a novel concept, there is an emerging consensus that the patient experience is a fundamental aspect of provider quality; one that complements established clinical process and
Jason Wolf, William Lehrman, Wolf, Jason A, PhD, Lehrman, William, PhD, Silvera, Geoffrey, MHA, Jason A Wolf, Geoffrey Silvera   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The perioperative patient experience of hand and wrist surgical patients: An exploratory study using patient journey mapping [PDF]

, 2018
Patient-centred care is becoming more important in healthcare. The success of patient-centred care can be assessed by exploring the patient experience through a patient journey map.
Marijke Melles, Melles, M., Kraan, G.A. (author), Melles, M. (author), Porsius, J.T., Kraan, Gerald, Melles, Marijke, Else F. de Ridder, Dekkers, T., Porsius, Jarry T, Tessa Dekkers, Gerald Kraan, Kraan, G.A., de Ridder, Else F. (author), Jarry T Porsius, de Ridder, Else F., Jarry Porsius, Else de Ridder, Porsius, J.T. (author), Dekkers, T. (author), Dekkers, Tessa   +20 more
core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source