Results 181 to 190 of about 543,181 (304)

Early identification of atopic dermatitis patients in need of systemic immunosuppressive treatment [PDF]

Clinical & Experimental Allergy, 2019
Daphne S. Bakker, Julia Drylewicz, Stefan Nierkens, Edward F. Knol, Barbara Giovannone, Eveline M. Delemarre, Jorien van der Schaft, Deepak M. W. Balak, Marjolein S. de Bruin‐Weller, Judith L. Thijs   +9 more
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Impact of Information Technology on Emergency Health Care Outcomes [PDF]

This paper analyzes the productivity of technology and job design in emergency response systems, or 911 systems.' During the 1990s, many 911 systems adopted Enhanced 911' (E911), where information technology is used to link automatic caller ...
Scott Stern, Susan Athey
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

When continuity of care breaks down: A systems failure in identification of osteoporosis risk in older patients treated for minimal trauma fractures

, 2008
Objective: Minimal trauma fractures may be the first indication of osteoporosis. Our aim was to determine the proportion of patients who underwent bone density testing for osteoporosis of those with a minimal trauma wrist fracture treated in the ...
Kelly, Anne-Maree, Clooney, Megan, Kerr, Debra, Ebeling, Peter   +3 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Patient perspectives of telemedicine quality

, 2014
Cynthia M LeRouge,1 Monica J Garfield,2 Alan R Hevner3 1Saint Louis University, St Louis, MO, 2Bentley University, Waltham, MA, 3University of South Florida, Tampa, FL, USA Background: The purpose of this study was to explore the quality attributes ...
Garfield MJ, Hevner AR, LeRouge CM
core  

Mobile Health (<i>mHealth</i>) Technology for Early Detection of Psychosocial Distress in Cancer Patients: <i>A Scoping Review</i>. [PDF]

Cancer Manag Res
Hernawaty T, Suryani S, Maryati I, Susanti RD, Maharani AY, Syafaat FA, Sundari NF, Aisyah TS, Erlindasari S.   +8 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Identification of Patients for a Community Health Worker Program Using an Artificial Intelligence Algorithm. [PDF]

Learn Health Syst
Savitz ST, Broderick B, Paul MM, Bonner TJ, Ridgeway JL, Kall M, Njeru JW.   +6 more
europepmc   +1 more source