Results 171 to 180 of about 543,181 (304)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

An Innovative Patient Stratification Tool Integrating Clinical and Economic Data for Benchmarking Oncology and Hematology Care: The PATONCOS System. [PDF]

J Clin Med
Moreno-Díaz R, Melgarejo-Ortuño A, Monje-García B, Delgado-Téllez de Cepeda L, Fernández-Román AB, Manso-Manrique M, Letéllez-Fernández J, Candel-García B, Sánchez-Guerrero A, Amor-García MÁ, García-Gil M, Valverde-Merino MI, García-Sánchez FJ, Calleja-Hernández MÁ.   +13 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Patient Identification And Hospital Information Management Systems In Sub-Saharan Africa: A Prospective Study In Rwanda And Burundi

, 2013
For many sub-Saharan health facilities, accurate patient identification remains a challenge. Poor national person identification systems, inefficient identification procedures, the use of weak search criteria and sometimes fraudulent practice consist ...
Van Bastelaere, Steven, Nyssen, Marc, Verbeke, Frank   +2 more
core  

Quality and patient safety surveillance systems in healthcare settings: a rapid realist review. [PDF]

BMJ Open
Ertuğrul B, Kaur Dullat J, McDonnell T, O'Dowd M, McAuliffe E.   +4 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

De-identification of intensive care unit patient records

, 2003
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.Includes bibliographical references (leaf 34).The creation of systems for assembling and analyzing medical data is currently one of the ...
Levine, Jason M. (Jason Michael), 1981-
core  

A Competency Framework for Medical AI Education: Mixed Methods Study. [PDF]

JMIR Med Educ
Cai C, Zhu G, Zhou SM, Ng O, Duell J, Ho WK, Chen DM, Lee B, Li F, Liu S, Sudarshan V, Wang LR, Choi C, Fan X.   +13 more
europepmc   +1 more source

Data Mining for the Unique Identification of Patients in the National Healthcare Systems

Proceedings of the International Conference on Operations Research and Enterprise Systems, 2015
Diana G. Ramíu Ríos, Laura P. Manotas Romero, Heyder Paez-Logreira, Luis Ramírez, Yohany Andrés Jimenez Florez   +4 more
openaire   +1 more source