Results 81 to 90 of about 4,427,780 (264)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

All the Lonely People

Journal of Patient-Centered Research and Reviews, 2016
A primary care physician laments the loneliness apparent in many underserved patients and seeks closure in the death of one patient in particular.
John Brill
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Assessment of Effectiveness of Geologic Isolation Systems SYSTEMS APPROXIMATE SIMULATOR: FISCAL YEAR 1982 PROGRESS [PDF]

, 1982
The ISystemsl task of the Assessment of Effectiveness of Geologic Isolation Systems (AEGIS) Program is developing a Systems Approximate Simulator (SAS); a computer code of low-level technical complexity that incorporates the most significant waste ...
Petrie, G. M., Devary, J. L.
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Co-Designing a Patient-Facing Version of a Mental Healthcare Pathway for People Receiving Dialysis

A Community Advisory Committee comprised of nine members with lived experience of kidney failure, identified the need for a patient-facing version of a mental healthcare pathway for people receiving dialysis in Alberta, Canada.
Tourangeau, May, Johnstone, Sandy, Berendonk, Charlotte, Bolin, Monika, Zaman, Sabiha, Kemp, Kevin, Robison, Julie, Schick-Makaroff, Kara, Albers, Alexandra, Costley, Jeff, Lee, Loretta, LeRoux, Justin, Sawatzky, Richard, Albers, Alexandra,, Kemp, Kevin,, Johnstone, Sandy,, Berendonk, Charlotte,, Leroux, Justin,, Zaman, Sabiha,, Bolin, Monika,, Sawatzky, Richard,, Robison, Julie,, Costley, Jeff,, Tourangeau, May,, Schick-Makaroff, Kara,, Lee, Loretta,   +25 more
core   +1 more source

Improving the experience of patients in contact isolation by human-centered design: A proof of concept study using patient journey mapping

, 2021
Background: Patient information provision about isolation measures is often not standardized. Moreover, it is unclear what information patients and informal caregivers need to optimize their knowledge and actual experience of contact isolation.
Dekker, Mireille (author), Melles, M. (author), de Koning, Judith PM (author), van Mansfeld, Rosa (author), Sonneveld, M.H. (author), Jongerden, Irene P (author)   +5 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source