Results 131 to 140 of about 9,819 (266)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Process mining and customer journey mapping in healthcare: Enhancing patient-centred care in stroke rehabilitation

Digital Health
Background Patient-centred care and enhancing patient experience is a priority across Australia. Stroke rehabilitation has multiple consumer touchpoints that would benefit from a better understanding of customer journeys, subsequently impacting better ...
Ingy Shafei, Jonathan Karnon, Maria Crotty   +2 more
doaj   +1 more source

A Machine Learning Approach Using Topic Modeling to Identify and Assess Experiences of Patients With Colorectal Cancer: Explorative Study

JMIR Cancer
BackgroundThe rising number of cancer survivors and the shortage of health care professionals challenge the accessibility of cancer care. Health technologies are necessary for sustaining optimal patient journeys.
Kelly Voigt, Yingtao Sun, Ayush Patandin, Johanna Hendriks, Richard Hendrik Goossens, Cornelis Verhoef, Olga Husson, Dirk Grünhagen, Jiwon Jung   +8 more
doaj   +1 more source

Development of a Patient Journey Map for Improving Patient Experience and Quality of Atopic Dermatitis Care

Dermatology and Therapy
Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects both children and adults. AD increases the risk of developing comorbidities like asthma, allergic rhinitis and food allergies. AD patients face difficulties, including itching, lack of effective treatments, lack of funding and discomfort in seeking a diagnosis or treatment ...
Gastón Roustán, Marta Loro, Ángel Rosell, Belén Menchen, Olga Vicente, Marta Elosua-González, Juan L. Castaño, Catalina Peña, Olga Isidoro   +8 more
openaire   +5 more sources

The meaning of patient satisfaction : re-assessing a qualitative psychological research methodology [PDF]

, 2002
In a move towards a more informed understanding of the concept of satisfaction, this study aims to explore how thirty dermatology patients describe what it means to be satisfied with their healthcare.
Collins, Karen A, Collins, Karen A.
core  

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Patient-oriented medical care: features and prospects of the patient’s pathway map implementation

Рациональная фармакотерапия в кардиологии
The healthcare system operates under defined key performance indicators that must be met. However, its structure remains inherently fragmented, divided into hierarchical tiers of care delivery.
A. R Navasardyan, D. D. Makarova, M. V. Mikaelyan, A. I. Kabanets, K. V. Lobastov, V. V. Sytkov, S. Yu. Martsevich   +6 more
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Experiences of Child and Adolescent Psychiatric Patients Boarding in the Emergency Department from Staff Perspectives: Patient Journey Mapping. [PDF]

Adm Policy Ment Health, 2023
Wolff JC, Maron M, Chou T, Hood E, Sodano S, Cheek S, Thompson E, Donise K, Katz E, Mannix M.   +9 more
europepmc   +1 more source