Results 181 to 190 of about 122,545 (272)

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, EarlyView.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Mapping the vitiligo patient journey: from awareness to treatment or coping strategies

Frontiers in Rehabilitation Sciences
Y. Valle, T. Lotti, S. Towheed, J. Sigova, J. Sigova   +4 more
doaj   +1 more source

Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort

Annals of Neurology, EarlyView.
Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov, Ivana Dzinovic, Theresa Brunet, Vicente A. Yépez, Florian Hölzlwimmer, Elisabetta Indelicato, Birgit Assmann, Susann Badmann, Diana Ballhausen, Steffen Berweck, Felix Brechtmann, Melanie Brugger, Kevork Derderian, Felix Distelmaier, Philip Harrer, Denisa Harvanova, Petra Havrankova, Ann‐Kathrin Jaroszynski, Miriam Kolnikova, Robert Kopajtich, Anne Koy, Magdalena Krygier, Lukas Kunc, Katarina Kusikova, Oliver Maier, Maria Mazurkiewicz‐Bełdzińska, Christian Mertes, Ava Oberlack, Timo Roser, Alexandra Sitzberger, Ugo Sorrentino, Antonia M. Stehr, Katharina Vill, Matias Wagner, Holger Prokisch, Sylvia Boesch, Jan Necpal, Robert Jech, Juliane Winkelmann, Elisabeth Graf, Julien Gagneur, Matej Skorvanek, Michael Zech   +42 more
wiley   +1 more source

Using personas and journey maps as knowledge translation tools to enhance clinicians' interpretation of PROM scores. [PDF]

J Patient Rep Outcomes
Kwon JY, Moynihan M, Lee K, Remin S, Wolff AC.   +4 more
europepmc   +1 more source

High Prevalence of SOD1 Pathogenic Variants in the UK Biobank: Implications for Early Intervention in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective SOD1 is the second most frequently mutated gene in European patients with amyotrophic lateral sclerosis (ALS). Given the recent authorization of SOD1‐targeted antisense oligonucleotides for SOD1‐ALS, prompt screening for SOD1 mutations in patients with ALS patients is highly recommended.
Delia Gagliardi, Chiara Villella, Matteo Zanovello, Virginia Iacobelli, Stefania Corti, Giacomo Pietro Comi, Pietro Fratta, Henry Houlden, Arianna Tucci, Dario Ronchi   +9 more
wiley   +1 more source

Mapping evolving care needs in older adults with disabilities: a qualitative study. [PDF]

Sci Rep
Jin YX, Wang XP, Gong LL, Zhang H, Xie YX, Ling XH, Chen Q, Yang DH.   +7 more
europepmc   +1 more source

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, EarlyView.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source

Behavioural and social drivers of immunisation among zero dose children in pastoralist communities of Ethiopia: a qualitative study. [PDF]

BMJ Open
Biadiglgn MT, Gelana N, Girma E, Abebe F, Mon HS, Tadesse Y, Ayalew Kokebie M, Gedlu T, Alemayehu H, Bikes T, Eshetu Y, Kasaye M, Endale A, Sharma R, Getachew H.   +14 more
europepmc   +1 more source

Editorial: Vitiligo: from obscurity to spotlight - Advancing care with new therapies and AI. [PDF]

Front Med (Lausanne)
Valle Y, Lotti T.
europepmc   +1 more source

Mapping the patient journey of adult patients with Spinal Muscular Atrophy in Greece: key challenges and priorities for action. [PDF]

Orphanet J Rare Dis
Golna C, Tzavara C, Vasileiadi C, Golnas P, Binou K, Karras A, Souliotis K.   +6 more
europepmc   +1 more source