Results 181 to 190 of about 2,539,328 (219)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Associations Between the Nurse Practice Environment and Nurse-Sensitive Patient Outcomes: Empirical Research Quantitative. [PDF]

Nurs Open
Chau JPC, Lo SHS, Choi KC, Butt L, Tong DWK, Kwok AML, Chan ELS, Lee IFK, Lee DTF, McHugh MD, Thompson DR.   +10 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Biophilic design in hospital environments: a rapid review of nature-integrated strategies and patient outcomes. [PDF]

Front Public Health
Du Y, Xie M, Zou Y.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Prevalence, Clinical Profiles, Disease Severity, and Patient Outcomes of Alcoholic Liver Disease in a Tertiary Care Hospital of Nepal. [PDF]

Health Sci Rep
Joshi B, Challa U, Aayush, Hernandez R, Devkota K, Yadav P, Dominguez RJR, Jawad A, Mateen MA, Dirani NA.   +9 more
europepmc   +1 more source

Implementing an Acute Frailty Service in the Emergency Department: A Mixed-Methods Service Evaluation of Feasibility, Patient Outcomes and Experience. [PDF]

J Eval Clin Pract
Zhang Y, Green V, Montagu A.
europepmc   +1 more source

The Impact of Real-Time Data Analytics on Infection Prevention and Control Practices in Ophthalmology: A Nursing Perspective on Patient Outcomes and Cost-Effectiveness. [PDF]

Nurs Health Sci
Chen Z, Wu S, Zhou Y, Tang C.
europepmc   +1 more source

Automating Critical Care EEG: Enhancing Accuracy, Efficiency, and Patient Outcomes in Critical Care. [PDF]

Epilepsy Curr
Rubinos C, Amorim E, Rehim E, Rodriguez-Ruiz A, Zafar SF, Sheikh ZB, Bruzzone MJ.   +6 more
europepmc   +1 more source