Results 111 to 120 of about 232,369 (302)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Basic Hip Arthroscopy: Supine Patient Positioning and Dynamic Fluoroscopic Evaluation

, 2015
Hip arthroscopy serves as both a diagnostic and therapeutic tool for the management of various conditions that afflict the hip. This article reviews the basics of hip arthroscopy by demonstrating supine patient positioning, fluoroscopic evaluation of the
Austin V. Stone, M.D., Ph.D., Elizabeth A. Howse, M.D., Sandeep Mannava, M.D., Ph.D., Allston J. Stubbs, M.D., M.B.A.   +3 more
core   +1 more source

The Impact of Patient Positioning on Video Laryngoscopy-Guided Tracheal Intubation in Obese Patients: A Prospective Observational Study Comparing Ramped versus Sniffing Position

Bali Journal of Anesthesiology
Background: A successful tracheal intubation depends on the patient being positioned optimally, especially in obese patients who frequently have difficult airway anatomy.
Thomas Steffi, Thomas Derlin, Baby Julie Philipose, Parameswaran Satheedevi   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Polyphony and Polyphasia in Self and Knowledge [PDF]

, 2010
The purpose in this paper is to contribute towards an understanding of the link beween plurality of self and knowledge. The paper relates the concept of cognitive polyphasia with Bakhtin’s views on positioning and the polyphony of the person, and ...
Renedo, A
core  

Axillary Artery Aneurysm as an Unforeseen Complication of the Park Bench Position: A Case Report

Bali Journal of Anesthesiology
Proper patient positioning is critical in neurosurgery to optimize surgical access and minimize complications. The park bench (PB) position is frequently employed for posterior fossa procedures due to its neurosurgical advantages but carries risks of ...
Ikhwan Nasir Bin Idris
doaj   +1 more source

Does intraprocedure patient positioning affect outcome of chemical pleurodesis for malignant pleural effusion?

Ibom Medical Journal
Background: Chemical pleurodesis using tetracycline is an acceptable and commonly employed palliation for malignant pleural effusion. Rotation of patient during pleurodesis using the powder from tetracycline capsule is still practised in some centres ...
Akpan AF, Etiuma AU, Ekpe EE
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Evaluation of Accuracy and Limitation in Patient Positioning

, 2010
Propose: Patient positioning is a crucial part in radiation therapy. It is largely related to achieving the appropriate irradiation and the planned dose in tumor, and also reducing unnecessary dose in normal tissue.
金野 正裕, 688447, 688446, Konno, Masahiro   +3 more
core