Results 151 to 160 of about 465,365 (351)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

MODERN OPPORTUNITIES OF PRIMARY PROPHYLAXIS OF SUDDEN CORONARY DEATH FROM A POSITION OF EARLY CORRECTION OF ACTIVITY THE NEUROHORMONAL SYSTEMS AT PATIENTS WITH MYOCARDIAL INFARCTION

, 2011
R. D. Kurbanov, Г Муллабаева
openalex   +2 more sources

The effects of patient positioning on hemodynamic parameters [PDF]

, 2021

openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Pancreatic transplantation using duct occlusion technique [PDF]

, 1988
Abendroth, D., Illner, Wolf-Dieter, Land, Walter, Landgraf, R.   +3 more
core   +1 more source

ADAPTATION OF THOMAS AND JONES SPLINTS TO OBTAIN FIXATION OF THE ARM IN AN ABDUCTED POSITION WHILE THE PATIENT IS AMBULATORY [PDF]

, 1917
ROBERT B. OSGOOD
openalex   +1 more source

Polymorphism at position T-129C in the promoter region of ABCB1 gene in peptic ulcer patients: a case control study [PDF]

, 2020

openalex   +1 more source

Position statement on infection screening, prophylaxis, and vaccination in pediatric patients with rheumatic diseases and immunosuppressive therapies, part 2: infection prophylaxis [PDF]

, 2023
Daniel Clemente, Esmeralda Núñez Cuadros, Marisol Camacho Lovillo, Joan Calzada‐Hernández, Sara Guillén Martín, Laura Fernández Silveira, María José Lirola Cruz, Alfredo Tagarro, Rosa Alcobendas, Agustín López López, Miren Satrustegi Aritziturri, Cristina Calvo   +11 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Impact of Patient Positioning on Video Laryngoscopy-Guided Tracheal Intubation in Obese Patients: A Prospective Observational Study Comparing Ramped versus Sniffing Position

Bali Journal of Anesthesiology
Background: A successful tracheal intubation depends on the patient being positioned optimally, especially in obese patients who frequently have difficult airway anatomy.
Thomas Steffi, Thomas Derlin, Baby Julie Philipose, Parameswaran Satheedevi   +3 more
doaj   +1 more source